Skip Navigation



NDT Advance Access published online on March 30, 2009
Nephrology Dialysis Transplantation, doi:10.1093/ndt/gfp127
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
24/6/1999    most recent
gfp127v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Fraile, P.
Right arrow Articles by Tabernero, J. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fraile, P.
Right arrow Articles by Tabernero, J. M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author [2009]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org


Hypotension, as consequence of the interaction between tacrolimus and mirtazapine, in a patient with renal transplant

Pilar Fraile, Pedro Garcia-Cosmes, Tamara Garcia, Luis Corbacho, Marcos Alvarez and Jose Matias Tabernero

Service of Nephrology, University Hospital of Salamanca, Salamanca, Spain

Correspondence and offprint requests to: Pilar Fraile; E-mail: Pilarfg{at}usal.es



  Abstract

The prevalence of psychiatric disorders in dialyzed patients is estimated around 5–20% of the cases. This explains the high use of antidepressant drugs in these patients.

We present the case of a 68-year-old woman with a history of renal failure, with chronic hemodialysis and a depressive syndrome in treatment with Mirtazapine. In November 2008, the patient received a renal graft.

An immunosuppressant treatment was started with Basiliximab, Tacrolimus, Mycophenolate Mofetil, and corticosteroids. The patient did not present renal immediate renal function. Four days after the transplant, the treatment with Mirtazapine was re-applied, with an asymptomatic hypotension after 2 hours, and without surgical complications. Tacrolimus blood levels were higher than 15 ng/ml.

In our opinion, hypotension was a consequence of the interaction Mirtazapine-Tacrolimus in a patient without immediate renal function. This situation has not been described in the literature before, and hypotension could have had negative consequences in the evolution of the graft.

Keywords: haemodialysis; mirtazapine; renal transplant; tacrolimus

Received for publication: 8. 2.09
Accepted in revised form: 3. 3.09


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.