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NDT Advance Access published online on March 17, 2009
Nephrology Dialysis Transplantation, doi:10.1093/ndt/gfp083
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© The Author [2009]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org


This extraordinary extramedullary haematopoiesis*

Michael S. Goligorsky

Departments of Medicine and Pharmacology, Renal Research Institute, New York Medical College, Valhalla, NY 10595, USA

Correspondence and offprint requests to: M. S. Goligorsky, New York Medical College, 15 Dana Rd, Valhalla 10595, NY, USA. Tel: +(914)594-4730; Fax: +(914)594-4732; E-mail: michael_goligorsky@NYMC.edu

Keywords: haematopoietic stem cells; ischaemia; kidney

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In this issue of the Journal, Stroo et al. [1] published their findings on the engraftment of the intact and ischaemic kidney by haematopoietic stem cells (HSC). Specifically, these investigators demonstrated that systemically administered HSC preferentially migrate to the ischaemic kidney and that this process is SDF-1/CXCR4 independent. Indeed, ischaemia-induced retention of hypoxia-inducible factor-1 has been implicated in such a preferential migration to ischaemic areas, although induction of SDF-1 was believed to be necessary [2]. This requirement for SDF-1 chemokine is overridden in leukaemic . . . [Full Text of this Article]


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