Skip Navigation



NDT Advance Access published online on July 28, 2008
Nephrology Dialysis Transplantation, doi:10.1093/ndt/gfn420
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
24/1/130    most recent
gfn420v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Parks, J. H.
Right arrow Articles by Worcester, E. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Parks, J. H.
Right arrow Articles by Worcester, E. M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author [2008]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org


Urine pH in renal calcium stone formers who do and do not increase stone phosphate content with time

Joan H. Parks1, Fredric L. Coe1, Andrew P. Evan2 and Elaine M. Worcester1

1 Nephrology Section, Department of Medicine, University of Chicago, Chicago, IL 2 Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN, USA

Correspondence and offprint requests to: Elaine M. Worcester, Nephrology Section/MC 5100, University of Chicago, 5841 South Maryland Ave, Chicago, IL 60637, USA. Tel: +1-773-702-1475; Fax: +1-773-702-5818; E-mail: eworcest@medicine.bsd.uchicago.edu

Keywords: calcium phosphate; kidney stones; lithotripsy; urine pH

The first 150 words of the full text of this article appear below.



   Introduction
 
Most calcium stones are composed primarily of calcium oxalate (CaOx) [1]. Stones composed primarily (>50%) of calcium phosphate (CaP) are less common [2] and seem preferentially likely in women; we found that 47% of CaP stone formers (SF) were female, compared with only 26% of CaOx SF. Idiopathic CaOx SF have no evidence of renal epithelial cell injury on papillary biopsy [3], while CaP SF plug their inner medullary collecting ducts (IMCD) and ducts of Bellini with apatite crystals [4]. For this reason, formation of CaP stones may well be a clinically undesirable event.

It is therefore worrisome that we [2] and others [5] have noted an increase in the prevalence of CaP in stones over the past two decades. Mandel found increased CaP in recurrent stones. CaP SF have high urine CaP supersaturation (SS), due to high . . . [Full Text of this Article]



   Subjects and methods
 
Patients
Idiopathic calcium SF
Transformers
Transformers whose 24-h urine studies preceded transformation
Controls, who did not transform
Stone analysis
Laboratory evaluation
Clinical analysis
Calculations and statistical analysis


   Results
 
Comparison of urine and stone measurements between T and C
Comparison of urine and stone measurements between TP and C


   ESWL
 
ESWL and urine pH are not related
T were given more citrate and thiazide than C


   Discussion
 
Urine pH and SS CaP are higher in T versus C before transformation has occurred
Higher urine pH is not likely due to IMCD CaP deposits
The role of ESWL is unclear
T were given more citrate and thiazide than C but not clearly before transformation


   Summary
 

Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Am. Soc. Nephrol.Home page
E. M. Worcester and F. L. Coe
Does Idiopathic Hypercalciuria Trigger Calcium-Sensing Receptor-Mediated Protection from Urinary Supersaturation?
J. Am. Soc. Nephrol., August 1, 2009; 20(8): 1657 - 1659.
[Full Text] [PDF]