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NDT Advance Access published online on May 8, 2008
Nephrology Dialysis Transplantation, doi:10.1093/ndt/gfn243
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© The Author [2008]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org


Encrusted cystitis by Corynebacterium urealyticum: a case report with novel insights into bladder lesions

Dorella Del Prete1, Biagio Polverino1, Monica Ceol1, Daniela Vianello1, Federica Mezzabotta1, Emilia Tiralongo1, Massimo Iafrate2, Ettore De Canale3, Carlo Mengoli3, Marialuisa Valente4, Franca Anglani1 and Angela D’Angelo1

1 Nephrology Unit and Kidney Histomorphology and Molecular Biology Laboratory, Department of Medical and Surgical Sciences 2 Urology Unit 3 Histology, Microbiology and Medical Biotechnology Department 4 Department of Medical-Diagnostic Sciences, Institute of Pathological Anatomy, University of Padova, Padova, Italy

Correspondence and offprint requests to: Dorella Del Prete, Nephrology Unit, Department of Medical and Surgical Sciences, University of Padova, via Giustiniani 2, 35128 Padova, Italy. Tel: +39-049-8212146; Fax: +39-049-8212151; E-mail: dorella.delprete@unipd.it

Keywords: Corynebacterium urealyticum; cystitis; encrustation; osteogenic markers

The first 10% of the full text of this article appears below.



   Background
 
Corynebacterium urealyticum (CU) (formerly Corynebacterium group D2) is a gram-positive bacillus with a strong urease activity that can infect the lower (acute or chronic cystitis) and upper (pyelonephritis and encrusted pyelitis) urinary tract [1]. CU is a commensal skin organism that an estimated 12% of healthy individuals carry and it has been isolated in 30% of hospitalized patients. CU converts urea into ammonia, creating alkaline urine, which precipitates struvite and calcium phosphate crystals, forming stones and encrustations on the infected mucosa [2].

Prolonged vesical and ureteral catheterization is considered the most important risk factor for developing encrusted cystitis (EC) and encrusted pyelitis (EP); these procedures not only carry CU or other urea-splitting micro-organisms into the urinary tract, but may also create conditions, e.g. urothelial trauma, that increase the . . . [Full Text of this Article]



   Case report
 


   Discussion
 

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