NDT Advance Access published online on April 15, 2008
Nephrology Dialysis Transplantation, doi:10.1093/ndt/gfn179
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The HLA-DRB1*1501 allele is prevalent among Japanese patients with anti-glomerular basement membrane antibody-mediated disease
1 Department of Internal Medicine, Division of Nephrology and Rheumatology, Aichi Medical University School of Medicine, Aichi 480-1195 2 Third Department of Internal Medicine, Akita University School of Medicine, 1-1-1 Hondo, Akita City, Akita 010-8543 3 Department of Medicine, Division of Nephrology, Fujita Health University School of Medicine, Toyoake, Aichi 470-1192, Japan
Correspondence and offprint requests to: Hirokazu Imai, Nephrology and Rheumatology, Aichi Medical University School of Medicine, Nagakute, Aichi 480-1195, Japan. Tel: +81-561-62-3311; Fax: +81-561-62-6694; E-mail: imaihiro{at}aichi-med-u.ac.jp
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Abstract |
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Purpose. We aimed to clarify the relationship between HLA-DRB1*1501 and anti-glomerular basement membrane (GBM) antibody-mediated disease in Japanese patients.
Materials and methods. Samples were collected from 16 anti-GBM antibody-positive patients who were admitted to our department or related hospitals from December 1990 to October 2005. We analysed clinical and laboratory data, kidney biopsy findings, and the HLA-DR phenotypes and HLA-DRB1 alleles of the patients.
Results. Among the 16 patients, 15 had HLA-DR15 [the phenotype frequency (PF) was 93.8%], 7 were positive for DR4 (the PF was 43.8%) and 5 were positive for DR9 (the PF was 31.3%). The allele frequency of HLA-DRB1*1501 was 46.4% (13/28), which was significantly different from Japanese controls (11.6%) (P < 0.001). In contrast, the frequency of HLA-DRB1*1502 was not different from controls (0/28). The odds ratio of HLA-DRB1*1501 in these patients was 6.4 (95% CI: 2.4–16.5).
Conclusion. The present study demonstrated that Japanese patients with anti-GBM antibody-mediated disease are very likely to carry the HLA-DRB1*1501 but not the HLA-DRB1*1502 allele.
Keywords: anti-glomerular basement membrane antibody; Goodpasture's disease; HLA-DR15; HLA-DRB1*1501
Received for publication: 24. 1.07
Accepted in revised form: 6. 3.08
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