NDT Advance Access published online on December 8, 2007
Nephrology Dialysis Transplantation, doi:10.1093/ndt/gfm738
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Troponin T is an Independent Predictor of Mortality in Renal Transplant Recipients
1 Department of Clinical Biochemistry, Royal Victoria Hospital, Belfast, Northern Ireland BT12 6BA, UK 2 Department of Nephrology, Belfast City Hospital, Belfast, Northern Ireland BT12 6BA, UK
Correspondence and offprint requests to: Dr Grainne Connolly, Department of Clinical Biochemistry, Royal Victoria Hospital, Grosvenor Road, Belfast, Northern Ireland BT12 6BA, UK. Tel: +44-2890240503; Fax: +44-2890234029; E-mail: Grainne.Connolly{at}bll.n-i.nhs.uk
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Abstract |
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Background. Numerous reports have demonstrated an association between elevated Troponin T levels and adverse cardiovascular outcomes in patients with chronic kidney disease. However, whether raised Troponin T levels are an independent predictor of mortality in renal transplant recipients has not yet been established. The aim of this study was, therefore, to assess the use of Troponin T as a prognostic marker in a population of renal transplant recipients.
Methods. Three hundred and seventy-two asymptomatic renal transplant recipients were recruited between June 2000 and December 2002. Troponin T was measured at baseline and prospective follow-up data were collected at a median of 1739 days.
Results. In Kaplan-Meier analysis a Troponin T level 
0.03 µg/l was a significant predictor of mortality (P < 0.001). In Cox Regression analysis, an elevated Troponin T level remained a significant predictor of mortality following adjustment for traditional cardiovascular risk factors (P < 0.001) and following adjustment for estimated glomerular filtration rate and high sensitivity C reactive protein (P < 0.001).
Conclusions. Elevated Troponin T level is a strong independent predictor of all cause mortality in patients with a renal transplant. Troponin T, therefore, represents a promising biochemical marker that identifies those renal transplant recipients who are most likely to benefit from aggressive cardiovascular risk factor modification.
Keywords: cardiovascular disease; cardiovascular events; renal transplantation; risk factors; survival
Received for publication: 2. 1.07
Accepted in revised form: 20. 9.07
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  G. R. Shroff and B. L. Kasiske Troponin T is an independent predictor of mortality in renal transplant recipients Nephrol. Dial. Transplant., August 1, 2008; 23(8): 2707 - 2707. [Full Text] [PDF]
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G. Connolly Reply Nephrol. Dial. Transplant., August 1, 2008; 23(8): 2707 - 2708. [Full Text] [PDF]
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