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NDT Advance Access published online on November 28, 2007
Nephrology Dialysis Transplantation, doi:10.1093/ndt/gfm736
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© The Author [2007]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org


Association of Functional Haem Oxygenase-1 Gene Promoter Polymorphism with Polycystic Kidney Disease and IgA Nephropathy

Aisling E. Courtney1,2, Peter T. McNamee2, Shirley Heggarty3, Derek Middleton4 and A. Peter Maxwell1,2

1 Nephrology Research Group, Queen's University Belfast, Belfast BT9 7AB, UK 2 Regional Nephrology Unit, Belfast BT9 7AB, UK 3 Genomics Core Facility, School of Medicine, Queen's University Belfast, Regional Genetics Centre, Belfast BT9 7AB, UK 4 Northern Ireland Histocompatibility and Immunogenetics Laboratory, Belfast City Hospital, Belfast BT9 7AB, UK

Correspondence and offprint requests to: Dr Aisling E. Courtney, Regional Nephrology Unit, Belfast City Hospital-Level 11, Lisburn Road, Belfast BT9 7AB, UK. Tel: +44-2890329241; Fax: +44-2890263535; E-mail: aecourtney{at}doctors.org.uk



  Abstract

Background. Haem oxygenase-1 (HO-1) is a cytoprotective molecule that is reported to have a protective role in a variety of experimental models of renal injury. A functional dinucleotide repeat (GT)n polymorphism, within the HO-1 promoter, regulates HO-1 gene expression; a short number of repeats (S-allele <25) increases transcription. We report the first assessment of the role of this HO-1 gene promoter polymorphism in chronic kidney disease due to autosomal dominant polycystic kidney disease (ADPKD) and IgA nephropathy (IgAN).

Methods. The DNA from 160 patients (99% Caucasian) on renal replacement therapy (RRT) was genotyped. The primary renal disease was ADPKD in 100 patients and biopsy-proven IgAN in 60 patients.

Results. Overall, the mean age at commencement of RRT was not significantly different between patients with and without an S-allele (44.1 years versus 45.0 years, P = 0.64). In patients with ADPKD, the age at commencement of RRT was comparable regardless of the HO-1 genotype (47.7 years versus 46.7 years, P = 0.59). The same was true in patients with IgAN (38.3 years versus 42.2 years, P = 0.28).

Conclusion. This suggests that the functional HO-1 promoter polymorphism does not influence renal survival in CKD due to ADPKD or IgAN.

Keywords: gene polymorphism; haem oxygenase-1; IgA nephropathy; polycystic kidney disease; progression of kidney disease

Received for publication: 6. 8.07
Accepted in revised form: 19. 9.07


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