NDT Advance Access published online on October 2, 2007
Nephrology Dialysis Transplantation, doi:10.1093/ndt/gfm640
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Influenza Vaccination Does Not Result in an Increase in Relapses in Patients With ANCA-Associated Vasculitis
1 Department of Nephrology, University Medical Center Groningen, University of Groningen, PO Box 30001, 9700 RB, Groningen, The Netherlands 2 Department of Clinical Immunology, University Medical Center Groningen, University of Groningen, PO Box 30001, 9700 RB, Groningen, The Netherlands
Correspondence and offprint requests to: Correspondence and offprint requests to: Patricia M. Stassen, Department of Internal Medicine, Medisch Spectrum Twente, PO Box 50000, 7500 KA, Enschede, The Netherlands. Tel: +4619142; Fax: +31534619142; E-mail: p.m.stassen{at}int.umcg.nl
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Abstract |
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Background. Vaccination against influenza has been suggested to induce relapses of ANCA-associated vasculitis but evidence is lacking. In this study, we assessed whether vaccination against influenza increases the occurrence of relapses in patients with ANCA-associated vasculitis.
Methods. Two hundred and thirty consecutive patients with ANCA-associated vasculitis from our out-patient clinics of a tertiary referral center, with at least 1 year of follow-up, were included. Retrospectively, the relapse rate per 100 patients at risk in patients who had been vaccinated against influenza within the preceding year and in patients who not had been vaccinated within that time period were calculated.
Results. The relapse rate per 100 patients at risk was lower in patients who had been vaccinated against influenza (3.4) than in patients who had not been vaccinated (6.3), when analyzed for the entire year and for every quarter of the year. Also, the disease-free survival per separate year according to the vaccination status was lower in all 5 years in patients who had been vaccinated, being statistically significant in 2 years.
Conclusion. Vaccination against influenza does not increase the relapse rate in patients with ANCA-associated vasculitis.
Keywords: ANCA-associated vasculitis; autoimmune disease; influenza; relapse; vaccination
Received for publication: 1. 8.07
Accepted in revised form: 21. 8.07
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