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NDT Advance Access published online on October 19, 2007
Nephrology Dialysis Transplantation, doi:10.1093/ndt/gfm614
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© The Author [2007]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Angiotensin AT1 and AT2 receptors—the battle for health and disease

Helmy M. Siragy

Department of Medicine and Hypertension Center, Division of Endocrinology and Metabolism, University of Virginia Health System, Charlottesville, VA 22908, USA

Correspondence and offprint requests to: Dr Helmy M. Siragy, P.O. Box 801409, University of Virginia Health System, Charlottesville, VA 22908-1409, USA. Email: hms7a@virginia.edu

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   Influence of angiotensin AT1 and AT2 subtype receptors on functional molecules of glomerular slit diaphragm
 
Proteinuria is associated with progression to end stage renal disease. The exact mechanisms contributing to the development of this pathological condition are yet to be elucidated. In the June issue of the American Journal of Pathology, Suzuki et al. [1] investigated the role of angiotensin II (Ang II) type 1 (AT1) and type 2 (AT2) receptors in regulating the barrier functions of the slit diaphragm, a component of a filtration barrier of the kidney glomerulus, which prevent the leak of plasma proteins into urine. Both in vivo and in vitro studies were performed in female Brown Norway rats and in immortalized mouse podocytes. Rats developed proteinuria by the induction of nephropathy . . . [Full Text of this Article]



   Glomerular slit diaphragm
 


   Angiotensin AT1 and AT2 receptors cross talk
 


   Potential clinical implications
 

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