Skip Navigation



NDT Advance Access published online on September 22, 2007
Nephrology Dialysis Transplantation, doi:10.1093/ndt/gfm531
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
22/12/3660    most recent
gfm531v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Beckhoff, A.
Right arrow Articles by Schaub, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Beckhoff, A.
Right arrow Articles by Schaub, S.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author [2007]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Relapsing severe anaemia due to primary parvovirus B19 infection after renal transplantation: a case report and review of the literature

Angelika Beckhoff1, Ingrid Steffen2, Pierre Sandoz3, Hans H Hirsch4 and Stefan Schaub1

1Clinic for Transplantation Immunology and Nephrology, 2Division of Diagnostics, Institute for Medical Microbiology, University of Basel, Basel, 3Bürgerspital Solothurn, Solothurn, and 4Transplantation Virology and Molecular Diagnostics, Department of Clinical and Biological Sciences, Institute for Medical Microbiology, University of Basel, Basel, Switzerland

Correspondence and offprint requests to: Angelika Beckhoff, MD, Department of Nephrology, Kantonsspital Luzern, Luzern, Switzerland. Email: angelika.beckhoff@ksl.ch

Keywords: anaemia; Parvovirus B19; primary infection; renal transplantation

The first 10% of the full text of this article appears below.



   Introduction
 
In renal transplant recipients Parvovirus B19 (PB19) infection can lead to severe anaemia, due to lytical replication within erythroid progenitor cells. Clearance of PB19-infection and protective immunity is assumed to be provided by specific PB19-IgG-antibodies [1]. In fact, passive transfer of PB19-IgG-antibodies by means of intravenous immunoglobulin (IvIg) preparations is successfully used to treat PB19-related anaemia [1,2]; however, several reports have shown that PB19-related anaemia can recur despite treatment with IvIg [2–11].

In this report we describe in detail a renal transplant patient who experienced relapsing severe PB19-related anaemia and we reviewed the current literature regarding factors associated with relapsing disease. Our data suggest that primary PB19-infection after kidney transplantation and polyclonal T-cell depleting therapies are risk factors for relapsing PB19-related anaemia. In addition, they support the concept that a PB19-specific . . . [Full Text of this Article]



   Case report
 


   Review of the literature
 


   Discussion
 


   Supplementary material
 

Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?