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NDT Advance Access published online on August 23, 2007
Nephrology Dialysis Transplantation, doi:10.1093/ndt/gfm510
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© The Author [2007].
The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions@oxfordjournals.org

Serum levels of beta-trace protein and its association to diuresis in haemodialysis patients

Thomas Gerhardt1, Uwe Pöge1, Birgit Stoffel-Wagner2, Burkhard Klein1, Hans-Ulrich Klehr1, Tilman Sauerbruch1 and Rainer P. Woitas1

1Department of Internal Medicine I and 2Institute of Clinical Biochemistry, University of Bonn, Germany

Correspondence and offprint requests to: Dr Thomas Gerhardt, Department of Internal Medicine I, University Hospital, Sigmund-Freud-Str. 25, D-53105 Bonn, Germany. Email: thomas.gerhardt{at}ukb.uni-bonn.de



  Abstract

Background. Beta-trace protein (BTP) has been proposed as an alternative endogenous marker of the glomerular filtration rate. However, possible determinants of BTP in ESRD patients undergoing regular renal replacement therapy have not been evaluated.

Methods. Serum levels of BTP, beta-2-microglobulin, creatinine and urea were analysed before and after dialysis treatment in 73 patients [haemodialysis (HD) n = 52; haemodiafiltration (HDF) n = 21]. Patients were categorized into four groups with residual diuresis (RD) < 0.5 l/day (group 1; n = 24), 0.5–1 l/day (group 2; n = 18), 1.1–1.5 l/day (group 3; n = 12) and >1.5 l/day (group 4; n = 19). Subsequently RD was compared to pre-treatment levels of BTP.

Results. HD treatment did not affect BTP serum levels [pre-treatment 8.1 ± 4.1 mg/l (mean+SD) vs post-treatment 7.7 ± 4.1 mg/l; –0.6 ± 16.1%; ns]. However, in 6 out of 21 patients undergoing HDF BTP levels were reduced by more than 20%. Overall, the resulting decrease in serum concentration was minuscule (9.6 ± 6.2 vs 8.3 ± 4.9 mg/l; –14 ± 21.9%; P = 0.03). BTP serum levels were tightly associated to RD of the four groups. Comparison of BTP levels showed significant differences between patients of groups 1 vs 3 and 4 as well as 2 vs 4.

Conclusions. BTP serum levels may serve as a surrogate marker for residual renal function since HD and HDF do not exert clinical relevant alterations on them. Furthermore, BTP serum concentrations appear strongly associated to RD.

Keywords: beta-trace-protein; beta-2-microglobulin; haemodiafiltration; haemodialysis; residual renal function

Received for publication: 25.10.06
Accepted in revised form: 2. 7.07


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