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NDT Advance Access published online on September 24, 2007
Nephrology Dialysis Transplantation, doi:10.1093/ndt/gfm403
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© The Author [2007]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

The nephrin-based slit diaphragm: new insight into the signalling platform identifies targets for therapy

Petri Aaltonen1 and Harry Holthöfer1,2

1The Haartman Institute, University of Helsinki, Finland and 2Center for BioAnalytical Sciences, Dublin City University, Ireland

Correspondence and offprint requests to: Harry Holthöfer, MD, PhD, Professor, Center for BioAnalytical Sciences, Dublin City University, Ireland. Email: harry.holthofer@dcu.ie

Keywords: glomerulus; filtration barrier; slit diaphragm; nephrin; signal transduction; proteinuria; molecular biology; protein complexes

The first 10% of the full text of this article appears below.



   Introduction
 
The global epidemic of chronic kidney disease (CKD) is progressing at an alarming rate. Ranging from mild to a most severe state, already up to 11% of the general population is affected in the US, Australia, Japan and Europe [1,2]. With a simultaneous steady increase of type II diabetes and its associated kidney complications, particularly in India, China and South-East Asia, kidney-related diseases globally are rapidly escaping any present treatment options and resources.

In most cases of CKD, the first clinical sign is proteinuria. Thus, a better understanding of mechanisms controlling the kidney permeability barrier in health and disease is essential to design better early diagnostics and therapies, to act while permanent damage may still be preventable. The key to success . . . [Full Text of this Article]



   Focus on the podocyte
 


   The nephrin-link, a target for therapy
 


   Conclusion
 

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