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NDT Advance Access published online on June 7, 2007
Nephrology Dialysis Transplantation, doi:10.1093/ndt/gfm351
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© The Author [2007]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

IgA nephropathy in a patient with IgG lambda light-chain plasmacytoma: a rare coincidence

Terje Forslund1, Anu Sikiö2 and Jorma Anttinen3

1Division of Nephrology, 2Division of Hematology, Department of Medicine and 3Department of Pathology, Central Finland Health Care District Hospital, Jyväskylä, Finland

Correspondence and offprint requests to: T. Forslund, MD, PhD, Chief of Division of Nephrology, Department of Medicine, Central Finland Health Care District Hospital, FIN-40620 Jyväskylä, Finland. Email: terje.forslund@ksshp.fi

Keywords: haemodialysis; IgA-nephropathy; multiple myeloma; NF{kappa}B-inhibition; renal failure

The first 150 words of the full text of this article appear below.



   Introduction
 
Renal involvement in multiple myeloma (MM), which accounts for about 10% of all haematological malignancies, is not uncommon. Immunoglobulin A (IgA) nephropathy and IgA lambda myeloma with mesangial proliferative glomerulonephritis (GN) have been reported [1]. An interaction between mesangial cells and IgA as well as IgG immune complexes provides a possible mechanism for glomerular injury in IgA nephropathy [2]. IgA myelomatosis with nephritis and Henoch-Schoenlein purpura may coexist [3], and some have suggested a causal relationship between IgA nephropathy and IgA myeloma [4]. Unlike findings in patients with lupus-GN and other types of proliferative and membranous GN, patients with IgA nephropathy have positive staining for kappa- ({kappa}) and lambda-({lambda}) immunoglobulin in their kidney biopsies [5], with more intense staining of the {lambda}-light-chain than for the {kappa}-light-chain.

Activation of the transcription factor nuclear factor {kappa}B (NF-{kappa}B) has been . . . [Full Text of this Article]



   Case
 
Kidney biopsy
Clinical development


   Discussion
 

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