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NDT Advance Access published online on September 17, 2007
Nephrology Dialysis Transplantation, doi:10.1093/ndt/gfm277
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© The Author [2007]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Renal failure complicating myeloma in pregnancy

James C. Lee1, Ross S. Francis2, Steve Smith3, Richard Lee1 and Coralie Bingham1

1Royal Devon and Exeter Hospital, Exeter, UK, 2Nuffield Department of Surgery, John Radcliffe Hospital, Oxford, UK and 3Torbay Hospital, Torquay, UK

Correspondence and offprint requests to: Dr Coralie Bingham, Exeter Kidney Unit, Royal Devon and Exeter Hospital, Barrack Road, Exeter, EX2 5DW, UK. Email: c.bingham@exeter.ac.uk

Keywords: immune surveillance; MGUS; myeloma; myeloma kidney; pregnancy; renal failure

The first 150 words of the full text of this article appear below.



   Introduction
 
Multiple myeloma (MM) is a malignancy of plasma cells characterized by the production of a monoclonal immunoglobulin, or paraprotein, which can be detected in the serum and/or urine. The clinical features include bone pain, anaemia, hypercalcaemia, renal impairment, recurrent infections associated with immunoparesis, abnormal bleeding tendency, amyloid and hyperviscosity syndrome. In most cases the cause is unknown, although there is evidence for certain aetiological factors including monoclonal gammopathy of undetermined significance (MGUS) [1]. MGUS is characterized by the presence of a paraprotein in the serum but <10% plasma cells in the bone marrow. There are no bone lesions or immunoparesis. The paraprotein concentration is usually <20 g/l and stationary, whereas in myeloma it is >20 g/l and rising. Despite its association with myeloma, the factors involved in the progression of MGUS to myeloma are not well understood [1].

Myeloma developing under the age of 40 years . . . [Full Text of this Article]



   Case
 


   Discussion
 

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