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NDT Advance Access published online on March 29, 2007
Nephrology Dialysis Transplantation, doi:10.1093/ndt/gfm122
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© The Author [2007]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Klotho spins the thread of life—what does Klotho do to the receptors of fibroblast growth factor-23 (FGF23)?*

Tilman B. Drüeke1 and Dominique Prié2

1Inserm Unité 845 and Service de Néphrologie and 2Service de Physiologie-Explorations Fonctionnelles and Inserm Unité 845, Hôpital Necker, Assistance Publique-Hôpitaux de Paris and Faculté de Médecine René Descartes Paris 5, Paris, France

Correspondence and offprint requests to: T. B. Drüeke, MD, FRCP, Inserm Unité 845, Hôpital Necker, Tour Lavoisier, 161 rue de Sèvres, F-75743 Paris Cedex 15 France. Email: drueke@necker.fr

Keywords: FGF23; FGF receptors; kidney; Klotho; phosphate; vitamin D

The first 10% of the full text of this article appears below.

Klotho is one of the three goddesses of the Moirae, who in Greek mythology control the life and destiny of everyone. She is the goddess who helps life to unfold, in contrast to the (apoptotic) goddess Atropos, who cuts the thread of life.

Prolonging lifespan is probably the most important role of the ageing-suppressor gene Klotho, named after the Greek goddess. Klotho was identified 10 years ago, by the Japanese group of Kuro-o et al. [1]. They reported that a defect in Klotho gene expression in the mouse resulted in a syndrome that resembled human ageing, including a short lifespan, infertility, arteriosclerosis, skin atrophy, osteoporosis and emphysema. The gene encoded a membrane protein . . . [Full Text of this Article]



   Why is Klotho of particular interest for nephrology?
 


   Regulation of FGF23 signalling by Klotho
 


   Conversion by Klotho of canonical FGF receptor into FGF23-specific receptor
 


   Conclusion
 

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