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NDT Advance Access published online on January 8, 2007
Nephrology Dialysis Transplantation, doi:10.1093/ndt/gfl815
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© The Author [2007]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Lumping, splitting and mapping: assessing linkage in different ethnic groups for albuminuria and glomerular filtration rate in the HyperGen study

Scott M. Williams

Division of Cardiovascular Medicine, Center for Human Genetics Research, Vanderbilt University, Nashville, TN 37232, USA

Correspondence and offprint requests to: Scott M. Williams, Division of Cardiovascular Medicine, Center for Human Genetics Research, Vanderbilt University, Nashville, TN 37232, USA. Email: smwillams@cghr.mc.vanderbilt.edu

Keywords: albuminuria; ethnic differences; genetics; glomerular filtration rate

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The ability to map genes that predispose to complex disease has been an ongoing area of research for more than a decade, but results have often been less than satisfying in terms of discovering genes of major importance. One likely reason is that the phenotypes used in many linkage analyses have heterogeneous genetic causes, so that different loci may confer susceptibility in different families. Such a situation can lead to the inability to identify loci in studies, or alternatively, loci found in one study may not replicate in others. An example of this kind of situation is found in the genetic study of hypertension, where multiple genome screens have identified a variety of loci, several of which do not replicate [1,2]. How can investigators deal with such heterogeneity?

In their article in the current issue of NDT, . . . [Full Text of this Article]



   Splitting and lumping by geographic origin
 


   Lumping of phenotypic categories
 

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