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NDT Advance Access published online on November 28, 2006
Nephrology Dialysis Transplantation, doi:10.1093/ndt/gfl696
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© The Author [2006]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Successful living donor kidney transplantation across HLA and ABO incompatibilities

Colm C Magee1, Helen Mah2, Kathryn Tinckam1, Isabelle Wood2, Fang Ji2 and John Powelson3

1Renal Division, Brigham and Women's Hospital, Boston, 2Tissue Typing Laboratory, Brigham and Women's Hospital, Boston and 3Transplant Surgery, Indiana University School of Medicine, Indianapolis

Correspondence and offprint requests to: Colm C. Magee, MD, Renal Division, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA. Email: cmagee@partners.org

Keywords: ABO; desensitization; incompatability; rejection; transplant

The first 10% of the full text of this article appears below.

A 56-year-old white female presented for evaluation for kidney transplantation in November 2003. Her end-stage renal disease (ESRD) was presumed due to medullary sponge kidney associated with stones and infection and she had started haemodialysis in April 2003. Other medical history included hypertension and anaemia. She was otherwise well. She had had four pregnancies and had received blood transfusions. Examination was unremarkable.

Initial tests showed blood group ABO-O. Her current panel reactive antibody (PRA) was 64% by the complement-dependent cytotoxicity (CDC) method and the peak PRA, 5 months prior to that, was 100%. Flow PRA screening confirmed IgG antibodies against class I and II human leukocyte antigens (HLA). The cause of the sensitization to HLA antigens was presumed to be the pregnancies and transfusions. Her 37-year-old son was the only potential . . . [Full Text of this Article]



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