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NDT Advance Access first published online on December 5, 2006
This version published online on December 18, 2006
Nephrology Dialysis Transplantation, doi:10.1093/ndt/gfl637
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© The Author [2006]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

‘Old-for-old’—new strategies for renal transplantation

Wolfgang Arns1, Franco Citterio2 and Josep M. Campistol3

1Cologne General Hospital, Merheim Medical Center, Cologne, Germany, 2Department of Surgery, Catholic University, Rome, Italy and 3Department of Nephrology, Hospital Clínic, University of Barcelona, Spain

Correspondence and offprint requests to: J M Campistol, Servei de Nefrologia i Transplantament Renal, Renal Transplant Unit, Hospital Clínic, Universitat de Barcelona, 170, Villarroel, 08036 Barcelona, Spain. Email: jmcampis@clinic.ub.es

Keywords: calcineurin inhibitor; everolimus; ‘old-for-old’; proliferation signal inhibitors/mTOR inhibitors; renal transplantation

The first 150 words of the full text of this article appear below.



   Introduction
 
Over the past decade, there has been a dramatic increase in the number of patients awaiting kidney transplantation, resulting in a progressive increase in the time spent on waiting list and in the length of time patients are receiving dialysis [1]. Patient survival is lower in patients receiving dialysis than in those who receive a transplant. Furthermore, the duration of pre-transplant dialysis is an important risk factor for both graft and patient survival post-transplantation. Indeed, 10-year graft survival of cadaveric kidney transplantation for patients undergoing pre-emptive transplantation is significantly higher than for patients transplanted when receiving dialysis (69% vs 39% for 24 months on dialysis, respectively) [2]. Reducing the waiting list time improves all aspects of chronic kidney failure, therefore, it is of utmost importance that the transplant community assesses measures to increase donor availability. Age-matching of donors and recipients is one way of expanding the . . . [Full Text of this Article]



   Expanding the donor pool
 


   ‘Old-for-old’ renal transplantation
 


   Impact of donor age
 


   Impact of recipient age
 


   Immunosuppressive regimens in ‘old-for-old’ transplantation
 


   Conclusions
 

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