NDT Advance Access published online on August 8, 2006
Nephrology Dialysis Transplantation, doi:10.1093/ndt/gfl359
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Nephrology and Hypertension Department, Western Galilee Hospital, Nahariya, Israel
* To whom correspondence should be addressed. Background. The relationships between sleep quality, melatonin circadian rhythm and polymorphonuclear leucocyte (PMNL) priming during the night of dialysis treatment compared with a night without dialysis were studied in a group of nocturnal haemodialysis (HD) patients. Methods. Twenty-eight long intermittent nocturnal HD patients were included. Sleep quality was assessed by a questionnaire and wrist actigraphy. Plasma melatonin levels were assayed every 2 h, from 9 p.m. to 5 a.m. PMNL priming was assessed by the rate of superoxide release from separated PMNLs at 9 p.m. and 5 a.m., on a night of dialysis and a night with sleepover in the dialysis unit without being dialysed. Results. Melatonin levels increased similarly during a night with and without dialysis, reaching peak level at 5 a.m. Most (73%) of the patients had severe sleep disturbances. A significant negative correlation was found between the sleep quality score, the rate of superoxide release from separated PMNLs and melatonin levels. While during a night without dialysis a significant reduction of the rate of superoxide release was found at 5 a.m. (compared with 9 p.m.), no significant reduction was observed when the patients were dialysed. Patients with flat melatonin curves, with <10 pg/ml, showed a faster rate of superoxide release than those with higher levels. Conclusions. The nocturnal HD process does not affect plasma melatonin levels or rhythms, suggesting that melatonin is not dialysed. Higher endogenous melatonin levels are associated with better sleep and lower PMNL priming. The lower PMNL priming in patients with higher plasma melatonin levels suggests that melatonin overrides the oxidative burden induced by the dialysis process.
Received March 16, 2006
Accepted May 23, 2006
Original Article
Polymorphonuclear leucocyte priming in long intermittent nocturnal haemodialysis patients--is melatonin a player?
Ronit Geron 1 *, Revital Shurtz-Swirski 2, Shifra Sela 3, Yevgeny Gurevitch 1, Tatiana Tanasijtchouk 1, Zila Shenn Orr 4, Galina Shkolnik 1, Olga Tanhilevski 1, and Batya Kristal 5
2 Eliachar Research Laboratory, Western Galilee Hospital, Nahariya, Israel
3 Eliachar Research Laboratory, Western Galilee Hospital, Nahariya, Israel; Bruce Rappaport Faculty of Medicine, Technion, Israel
4 Endocrinology Lab, Rambam Hospital, Haifa, Israel
5 Nephrology and Hypertension Department, Western Galilee Hospital, Nahariya, Israel; Bruce Rappaport Faculty of Medicine, Technion, Israel
Ronit Geron, E-mail: ronit.geron{at}naharia.health.gov.il
Abstract 
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  B. C. P. Koch, K. van der Putten, E. J. W. Van Someren, J. P. M. Wielders, P. M. Ter Wee, J. E. Nagtegaal, and C. A. J. M. Gaillard Impairment of endogenous melatonin rhythm is related to the degree of chronic kidney disease (CREAM study) Nephrol. Dial. Transplant., September 19, 2009; (2009) gfp493v1. [Abstract] [Full Text] [PDF]
|
|