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NDT Advance Access published online on July 22, 2006
Nephrology Dialysis Transplantation, doi:10.1093/ndt/gfl356
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© The Author [2006]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Received February 10, 2006
Accepted May 22, 2006

Original Article

Effects of L-carnitine infusions on inflammatory and nutritional markers in haemodialysis patients

Murat Duranay 1 *, Hatice Akay 1, Fatma Meriç Yilmaz 2, Mehmet Senes 2, Nurçin Tekeli 1, and Dogan Yücel 2

1 Dialysis Unit, Ministery of Health, Ankara 06340, Turkey
2 Clinical Biochemistry Laboratory of Ankara Hospital, Ministery of Health, Ankara 06340, Turkey

* To whom correspondence should be addressed.
Murat Duranay, E-mail: fatmamericyilmaz{at}hotmail.com



  Abstract

Background. Carnitine loss through dialysis membranes is shown to be related to the lack of carnitine in long-term haemodialysis patients. It has been previously reported that haemodialysis patients might have benefited from carnitine supplementation.

Methods. A total of 21 chronic haemodialysis patients maintaining carnitine supplementation and 21 controls (haemodialysis patients not receiving carnitine) were included in the study. L-carnitine was used intravenously three times a week after each haemodialysis session, at a 20 mg/kg dose. C-reactive protien (CRP), lipid profile, transferrin, total protein and albumin levels were determined at baseline after 3 and 6 months of treatment, and compared with the control group.

Results. CRP levels were significantly decreased in carnitine group in contrast to the increase in the control group. Transferrin, total protein and albumin levels and body mass index (BMI) of the patients rose in the carnitine group.

Conclusions. There was a significant benefit of L-carnitine on CRP, transferrin, total protein and albumin levels of the haemodialysis patients.

Keywords: CRP; haemodialysis; inflammation; L-carnitine; nutrition.
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