NDT Advance Access published online on July 4, 2006
Nephrology Dialysis Transplantation, doi:10.1093/ndt/gfl325
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1 Department of Nephrology, Iwate Prefectural Central Hospital, 1-4-1, Ueda, Morioka 020-0066, Japan
* To whom correspondence should be addressed. Background. Tranilast is an antifibrotic drug known to suppress collagen synthesis by fibroblasts by interfering with the effects of TGF- Methods. Among out-patients with diabetes mellitus, we selected patients with (i) urinary albumin excretion of 30-1000 mg/g creatinine (/gCr) in the first morning urine, (ii) serum creatinine (SCr) Results. At baseline, no significant differences were observed in SCr, HbA1c, blood pressure and U-A excretion between the T(+) and T(-) groups, but U-IV excretion in the T(+) group was higher than in the T(-) group (6.4 ± 0.66 vs 3.7 ± 0.36 µg/gCr, mean ± SEM, P < 0.01). At 1 year, SCr was not different from the baseline in either group. In the T(+) group, however, excretion rates of both U-IV and U-A tended to decrease with time, and after 1 year, were significantly decreased compared with excretion at baseline (U-A: 279 ± 78 to 191 ± 62 mg/gCr; P = 0.049, U-IV: 6.4 ± 0.66 to 4.4 ± 0.99 µg/gCr; P = 0.02). In contrast, in the T(-) group, excretion of both U-A and U-IV tended to increase with time. The changes of both U-A and U-IV excretions in the two groups took statistically different trends through tranilast treatment (P = 0.01 and P = 0.04, respectively). Conclusions. Our results suggest that tranilast could be therapeutically beneficial in early-stage DN.
Received March 10, 2006
Accepted May 8, 2006
Original Article
Effect of tranilast in early-stage diabetic nephropathy
Jun Soma 1 *,
Kozo Sato 1,
Harutaka Saito 1,
and
Yoshinori Tsuchiya 1
Jun Soma, E-mail: sjun{at}chuo-hp.pref.iwate.jp
Abstract 
. We recently reported that it slowed the progression rate of advanced diabetic nephropathy (DN) by reducing the accumulation of collagens in renal tissue. The present study was undertaken to examine the effect of tranilast on early-stage DN.
1.2 mg/dl and no haematuria and (iii) currently taking an angiotensin-converting enzyme inhibitor or angiotensin receptor blocker. Twenty patients fulfilled the criteria, of whom 10 were selected at random and commenced on tranilast [100 mg, 3 times daily; T(+) group]. The remaining 10 patients comprised the T(-) group. Excretion of both urinary type IV collagen (U-IV) and albumin (U-A) in the first morning urine was measured every 3 months. The follow-up period was 1 year.
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