Skip Navigation



NDT Advance Access published online on June 9, 2006
Nephrology Dialysis Transplantation, doi:10.1093/ndt/gfl292
This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
21/9/2446    most recent
gfl292v2
gfl292v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Kielstein, J. T.
Right arrow Articles by Fliser, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kielstein, J. T.
Right arrow Articles by Fliser, D.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author [2006]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Received February 27, 2006
Accepted April 28, 2006

Original Article

Symmetric dimethylarginine (SDMA) as endogenous marker of renal function--a meta-analysis

Jan T. Kielstein 1 *, Shelley R. Salpeter 2, Stefanie M. Bode-Boeger 3, John P. Cooke 4, and Danilo Fliser 5

1 Department of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA; Department of Internal Medicine, Division of Nephrology, Medical School Hannover, Germany
2 Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA
3 Institute for Clinical Pharmacology, Otto-von-Guericke University, Magdeburg, Germany
4 Department of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA
5 Department of Internal Medicine, Division of Nephrology, Medical School Hannover, Germany

* To whom correspondence should be addressed.
Jan T. Kielstein, E-mail: Kielstein{at}yahoo.com



  Abstract

Background. Dosing of most drugs must be adapted in renal insufficiency, making accurate assessment of renal function essential in clinical medicine. Furthermore, even modest impairment of renal function has been recognized as a cardiovascular risk factor. The purpose of this analysis was to identify the role of symmetric dimethylarginine (SDMA), the structural isomer of the cardiovascular risk marker asymmetric dimethylarginine, as an endogenous marker of renal function.

Methods. Comprehensive searches of Medline and the Cochrane Library from 1970 to February 2006 were performed to identify studies that evaluated the correlation between SDMA and renal function. The search was augmented by scanning references of identified articles and reviews. The correlation coefficients (R) were recorded from each study for the values of 1/SDMA and clearance estimates and for SDMA and creatinine levels. The summary correlation coefficients with 95% confidence intervals (CIs) were pooled using the random-effects method.

Results. In 18 studies involving 2131 patients systemic SDMA concentrations correlated highly with inulin clearance [R = 0.85 (CI 0.76-0.91, P < 0.0001)], as well as with various clearance estimates combined [R = 0.77 (CI 0.65-0.85, P < 0.0001)] and serum creatinine [R = 0.75 (CI 0.46-089, P < 0.0001)].

Conclusions. SDMA exhibits some properties of a reliable marker of renal function. Future studies have to clarify whether SDMA is indeed suited to improve diagnosis and eventually optimize care of patients.

Keywords: creatinine; glomerular filtration rate; MDRD fromula; renal function; SDMA.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Nephrol Dial TransplantHome page
A. Surdacki, E. Marewicz, E. Wieczorek-Surdacka, T. Rakowski, G. Szastak, J. Pryjma, D. Dudek, and J. S. Dubiel
Synergistic effects of asymmetrical dimethyl-L-arginine accumulation and endothelial progenitor cell deficiency on renal function decline during a 2-year follow-up in stable angina
Nephrol. Dial. Transplant., September 3, 2009; (2009) gfp439v1.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
Z. Wang, W. H. W. Tang, L. Cho, D. M. Brennan, and S. L. Hazen
Targeted Metabolomic Evaluation of Arginine Methylation and Cardiovascular Risks: Potential Mechanisms Beyond Nitric Oxide Synthase Inhibition
Arterioscler Thromb Vasc Biol, September 1, 2009; 29(9): 1383 - 1391.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
J. G. Ayer, J. A. Harmer, S. Nakhla, W. Xuan, M. K.C. Ng, O. T. Raitakari, G. B. Marks, and D. S. Celermajer
HDL-Cholesterol, Blood Pressure, and Asymmetric Dimethylarginine Are Significantly Associated With Arterial Wall Thickness in Children
Arterioscler Thromb Vasc Biol, June 1, 2009; 29(6): 943 - 949.
[Abstract] [Full Text] [PDF]

Home page
 CJASNHome page
J. M. Young, N. Terrin, X. Wang, T. Greene, G. J. Beck, J. W. Kusek, A. J. Collins, M. J. Sarnak, and V. Menon
Asymmetric Dimethylarginine and Mortality in Stages 3 to 4 Chronic Kidney Disease
Clin. J. Am. Soc. Nephrol., June 1, 2009; 4(6): 1115 - 1120.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
E. Schepers, G. Glorieux, A. Dhondt, L. Leybaert, and R. Vanholder
Role of symmetric dimethylarginine in vascular damage by increasing ROS via store-operated calcium influx in monocytes
Nephrol. Dial. Transplant., May 1, 2009; 24(5): 1429 - 1435.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
S. S. Billecke, L. G. D'Alecy, R. Platel, S. E. Whitesall, K. A. Jamerson, R. L. Perlman, and C. A. Gadegbeku
Blood content of asymmetric dimethylarginine: new insights into its dysregulation in renal disease
Nephrol. Dial. Transplant., February 1, 2009; 24(2): 489 - 496.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
B. Ellger, M. C. Richir, P. A. M. van Leeuwen, Y. Debaveye, L. Langouche, I. Vanhorebeek, T. Teerlink, and G. Van den Berghe
Glycemic Control Modulates Arginine and Asymmetrical-Dimethylarginine Levels during Critical Illness by Preserving Dimethylarginine-Dimethylaminohydrolase Activity
Endocrinology, June 1, 2008; 149(6): 3148 - 3157.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
F. Palm, M. L. Onozato, Z. Luo, and C. S. Wilcox
Dimethylarginine dimethylaminohydrolase (DDAH): expression, regulation, and function in the cardiovascular and renal systems
Am J Physiol Heart Circ Physiol, December 1, 2007; 293(6): H3227 - H3245.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
M. Juonala, J. S.A. Viikari, G. Alfthan, J. Marniemi, M. Kahonen, L. Taittonen, T. Laitinen, and O. T. Raitakari
Brachial Artery Flow-Mediated Dilation and Asymmetrical Dimethylarginine in the Cardiovascular Risk in Young Finns Study
Circulation, September 18, 2007; 116(12): 1367 - 1373.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
Y. Matsumoto, S. Ueda, S.-i. Yamagishi, K. Matsuguma, R. Shibata, K. Fukami, H. Matsuoka, T. Imaizumi, and S. Okuda
Dimethylarginine Dimethylaminohydrolase Prevents Progression of Renal Dysfunction by Inhibiting Loss of Peritubular Capillaries and Tubulointerstitial Fibrosis in a Rat Model of Chronic Kidney Disease
J. Am. Soc. Nephrol., May 1, 2007; 18(5): 1525 - 1533.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
C. Zoccali, R. Maas, S. Cutrupi, P. Pizzini, P. Finocchiaro, F. Cambareri, V. Panuccio, C. Martorano, F. Schulze, G. Enia, et al.
Asymmetric dimethyl-arginine (ADMA) response to inflammation in acute infections
Nephrol. Dial. Transplant., March 1, 2007; 22(3): 801 - 806.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
S. Tatematsu, S. Wakino, T. Kanda, K. Homma, K. Yoshioka, K. Hasegawa, N. Sugano, M. Kimoto, T. Saruta, and K. Hayashi
Role of Nitric Oxide-Producing and -Degrading Pathways in Coronary Endothelial Dysfunction in Chronic Kidney Disease
J. Am. Soc. Nephrol., March 1, 2007; 18(3): 741 - 749.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.