Skip Navigation



NDT Advance Access published online on May 23, 2006
Nephrology Dialysis Transplantation, doi:10.1093/ndt/gfl236
This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
21/9/2521    most recent
gfl236v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Sung, J.-M.
Right arrow Articles by Huang, J.-J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sung, J.-M.
Right arrow Articles by Huang, J.-J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author [2006]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Received February 7, 2006
Accepted April 3, 2006

Original Article

The role of oral dryness in the interdialytic weight gain by diabetic and non-diabetic haemodialysis patients

Junne-Ming Sung 1, Shih-Chen Kuo 2, How-Ran Guo 3, Shu-Fen Chuang 4, Szu-Yuan Lee 5, and Jeng-Jong Huang 1 *

1 Department of Internal Medicine, National Cheng Kung University Hospital, Taiwan
2 Institute of Clinical Pharmacy, College of Medicine, National Cheng Kung University, Tainan, Taiwan
3 Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan
4 Department of Operative Dentistry, National Cheng Kung University Hospital, Taiwan
5 Department of Internal Medicine, Kuo's General Hospital, Tainan, Taiwan

* To whom correspondence should be addressed.
Jeng-Jong Huang, E-mail: jjhuang{at}mail.ncku.edu.tw



  Abstract

Background. Factors influencing the percentage of daily interdialytic weight gain (IDWG%) and their interactions in haemodialysis (HD) patients have not been well-defined, especially in diabetic patients. We analysed contributing factors for the increase of IDWG%, particularly xerostomia (oral dryness), among diabetic and non-diabetic HD patients.

Methods. We collected 3 month prospective data in 184 stable HD patients (116 non-diabetic and 68 diabetic), including assessments of xerostomia by 100 mm visual analog scales (VASs), and the unstimulated whole salivary (UWS) flow rate was measured in 91 patients by a spitting method.

Results. Diabetic patients have higher IDWG% (P = 0.042) and VAS oral dryness score (P = 0.021), whereas, have lower UWS (P = 0.032). In non-diabetic patients, the VAS oral dryness score, age, Kt/V and blood urea nitrogen (BUN) level correlated independently with IDWG%. In diabetic patients, the haemoglobin A1C (HbAIC) correlated significantly with IDWG% after controlling for age, Kt/V and BUN level; however, when VAS oral dryness score was introduced into the regression model, the effect of HbAIC became marginally significant (P = 0.073) while the VAS oral dryness score became significantly correlated with IDWG%. The increases in IDWG% per unit change in VAS oral dryness score did not show significant difference between the non-diabetic and total diabetic patients; however, it was larger in patients with HbAIC ≥9%.

Conclusions. Xerostomia plays a significant role in increasing IDWG% among diabetic and non-diabetic HD patients. In diabetic patients, the increased IDWG% associated with the increasing HbA1C level is largely dependent on the severity of xerostomia, and we speculate that insulin deficiency may operate synergistically with xerostomia in increasing IDWG% in patients with HbA1C ≥9%.

Keywords: diabetes mellitus; haemodialysis; interdialytic weight gain; xerostomia.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Nephrol Dial TransplantHome page
L. Niepolski, A. E. Grzegorzewska, and J. Szymas
Nodular pulmonary amyloidosis and Sjogren's syndrome in a patient treated with intermittent haemodialysis (IHD)
Nephrol. Dial. Transplant., May 1, 2007; 22(5): 1485 - 1486.
[Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.