NDT Advance Access first published online on August 5, 2006
This version published online on August 25, 2006
Nephrology Dialysis Transplantation, doi:10.1093/ndt/gfl203
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Basilicata Referral Centre for Transplantation, Hospital of Matera, Italy
* To whom correspondence should be addressed. Background. Color Doppler ultrasonography of intrarenal arterial resistance index (RI), performed early after kidney transplant, has proven to reliably predict short-term allograft function. The aim of this study was to assess whether it could also predict long-term renal function. Methods. We retrospectively analysed 76 kidney transplant patients who underwent RI assessment within 1 month after the transplant, subdivided into two groups according to RI values, lower (group A) or higher (group B) than its median value (0.635). Results. Compared with group A subjects, the patients of group B were older at the time of transplant (42 ± 9 vs 35 ± 8 years; P = 0.001), the donor age was also older (41 ± 16 vs 33 ± 13 years; P = 0.02) and had a slightly higher proteinuria (0.54 ± 0.5 vs 0.32 ± 0.2 g/24 h; P = 0.02). Serum creatinine, ciclosporin or tacrolimus trough level, arterial blood pressure, number of human leukocyte antigen (HLA) mismatches, anti-hypertensive medications and incidence of delayed graft function were not significantly different between the two groups. By univariate analysis, RI turned out to directly correlate with the recipient age, donor age and daily proteinuria (P = 0.007, P = 0.0007 and P = 0.02, respectively). Multivariate analysis showed that only donor and recipient age maintained their independent predictive value on RI. Kaplan-Meier analysis, considering a serum creatinine increase >50% as the endpoint of the study, showed a statistically significant different graft survival in the two groups (log-rank test = 5.489; P = 0.01). The univariate relative risk of deterioration of graft function among patients with higher RI was 3.77. Proteinuria and recipient age increased the risk as well. Conclusions. Our data seem to suggest that early determination of RI can help predict long-term graft function in kidney transplant recipients. In this version, Table 2 has been updated.
Received December 3, 2005
Accepted March 21, 2006
Original Article
Early assessment of renal resistance index after kidney transplant can help predict long-term renal function
Angelo Saracino 1 *, Giovanni Santarsia 2, Angela Latorraca 1, and Vito Gaudiano 1
2 Division of Nephrology and Dialysis, Hospital of Matera, Italy
Angelo Saracino, E-mail: asaracino{at}inwind.it
Abstract 
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  A. Kolonko, J. Chudek, and A. Wicek Prediction of the severity and outcome of acute tubular necrosis based on continuity of Doppler spectrum in the early period after kidney transplantation Nephrol. Dial. Transplant., May 1, 2009; 24(5): 1631 - 1635. [Abstract] [Full Text] [PDF]
|
|