NDT Advance Access published online on March 22, 2006
Nephrology Dialysis Transplantation, doi:10.1093/ndt/gfl115
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 CNR-IBIM, National Research Council-Institute of Biomedicine, Clinical Epidemiology and Physiopathology of Renal Diseases and Hypertension, Reggio Calabria, Italy
* To whom correspondence should be addressed. Background. E-selectin is a cell surface glycoprotein that mediates the adhesion of leucocytes to vessels endothelium, an important early step in the atherosclerotic process. End-stage renal disease (ESRD) is a highly atherogenic disease but it is unknown whether genetic polymorphism(s) in the E-selectin gene plays a role in the severity of arterial damage in this condition. Method. In this study, we tested whether the Leu554Phe variant in the E-selectin gene is linked to carotid atherosclerosis in 134 well-characterized ESRD patients. The frequency of this polymorphism was also measured in a population sample of the same geographical area. Results. A total of 84% patients had the CC genotype, 13% had the CT genotype, 3% had the TT genotype and this distribution did not differ from that in the control population. Intima-media thickness (IMT) (P = 0.01) and cross-sectional area (P = 0.02) were significantly higher in patients with the T-allele than in those without this allele. Furthermore, the degree of carotid stenosis was significantly higher (P = 0.02) in patients with the T-allele than in CC patients. On multivariate analyses including the traditional and non-traditional risk factors, the Leu554Phe polymorphism was confirmed as an independent correlate of IMT (P = 0.02), cross-sectional area (P = 0.03) and carotid stenosis (P = 0.02). Conclusion. In ESRD, the Leu554Phe polymorphism of E-selectin gene is associated with the severity of carotid atherosclerosis, suggesting that genetically-determined alterations in the E-selectin molecule may render ESRD patients with this gene variant particularly susceptible to the detrimental effects of inflammation on the arterial wall.
Received February 7, 2006
Accepted February 22, 2006
Original Article
The E-selectin gene polymorphism and carotid atherosclerosis in end-stage renal disease
Alessandra Testa 1,
Francesco A. Benedetto 2,
Belinda Spoto 1,
Anna Pisano 1,
Giovanni Tripepi 1,
Francesca Mallamaci 1,
Lorenzo S. Malatino 3,
and
Carmine Zoccali 1 *
2 Cardiology Unit, Morelli Hospital, Reggio Cal, Italy
3 Department of Internal Medicine, Catania University, Catania, Italy
Carmine Zoccali, E-mail: carmine.zoccali{at}tin.it
Abstract 
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  M. I. Yilmaz, J. J. Carrero, A. Ortiz, J. L. Martin-Ventura, A. Sonmez, M. Saglam, H. Yaman, M. Yenicesu, J. Egido, and L. M. Blanco-Colio Soluble TWEAK Plasma Levels as a Novel Biomarker of Endothelial Function in Patients with Chronic Kidney Disease Clin. J. Am. Soc. Nephrol., November 1, 2009; 4(11): 1716 - 1723. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. T. Papas, C. K. Maltezos, N. Papanas, G. Kopadis, J. Marakis, E. Maltezos, and E. Bastounis High-Sensitivity CRP Is Correlated With Neurologic Symptoms and Plaque Instability in Patients With Severe Stenosis of the Carotid Bifurcation Vascular and Endovascular Surgery, June 1, 2008; 42(3): 249 - 255. [Abstract] [PDF]
|
|