Skip Navigation



NDT Advance Access published online on March 23, 2006
Nephrology Dialysis Transplantation, doi:10.1093/ndt/gfl066
This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
21/7/1803    most recent
gfl066v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Treckmann, J. W.
Right arrow Articles by Nagelschmidt, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Treckmann, J. W.
Right arrow Articles by Nagelschmidt, M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author [2006]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Received June 11, 2005
Accepted February 3, 2006

Original Article

Primary organ function of warm ischaemically damaged porcine kidneys after retrograde oxygen persufflation*

Jürgen W. Treckmann 1 *, Andreas Paul 1, Stefano Saad 2, Julia Hoffmann 3, Karl-Heinz Waldmann 3, Christoph E. Broelsch 1, and Manfred Nagelschmidt 4

1 Department for General, Visceral and Transplantation Surgery, University Hospital of Essen, Hufelandstr. 55, 45122 Essen, Germany
2 Clinic for Visceral, Vascular and Transplantation Surgery, University of Witten Herdecke, Hospital Cologne Merheim, Ostmerheimer Str. 200, 51109 Cologne, Germany
3 Clinic for Swine, Small Ruminants, Forensic Medicine and Ambulatory Services, Veterinary School of Hannover, Bischofsholer Damm 15, 31073 Hannover, Germany
4 Institute of Experimental Medicine, University of Cologne, Robert-Koch-Str. 10, 50931 Cologne, Germany

* To whom correspondence should be addressed.
Jürgen W. Treckmann, E-mail: j.treckmann{at}gmx.net



  Abstract

Background. As warm ischaemic damage is a major reason for the loss of donor organs, an experimental study was performed in order to evaluate retrograde oxygen persufflation (ROP) as a method to extend the warm ischaemic tolerance of kidneys.

Methods. Kidneys of 32 pigs were exposed to warm ischaemia for 60, 90 or 120 min. Then, 16 kidneys were subjected to ROP for 4 h at 4°C and 16 controls were stored in cold UW-solution, followed by autotransplantation.

Results. Only in the group with 60 min warm ischaemic time and ROP did all animals survive the observation period of 7 days. In all other groups some animals died due to anuria. Short-term survivors in these groups had significantly higher creatinine levels.

Conclusions. In this setting, ROP was superior to cold storage when applied after 60 min of warm ischaemia. Clinical evaluation of ROP in the setting of marginal donors and non-heartbeating donation is recommended.

Keywords: kidney transplantation; non-heartbeating donors; retrograde oxygen persufflation; warm ischaemia.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.