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NDT Advance Access published online on October 18, 2005
Nephrology Dialysis Transplantation, doi:10.1093/ndt/gfi198
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© The Author [2005]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Received March 14, 2005
Accepted September 9, 2005

Dialysis and Transplantation News

The renal epidemiology and information network (REIN): a new registry for end-stage renal disease in France

Cécile Couchoud 1*, Bénédicte Stengel 2, Paul Landais 3, Jean-Claude Aldigier 4, François de Cornelissen 5, Christian Dabot 6, Hervé Maheut 7, Véronique Joyeux 8, Michèle Kessler 9, Michel Labeeuw 10, Hubert Isnard 11, and Christian Jacquelinet 1

1 REIN Registry, Agence de la biomédecine, La Plaine Saint Denis
2 INSERM U258, Research in Cardiovascular and Metabolic Epidemiology Villejuif
3 Université Paris-Descartes, Faculté de Médecine, Assistance Publique-Hôpitaux de Paris, EA222, Department of Biostatistics and Medical Informatics, Hôpital Necker-Enfants Malades
4 Limousin coordinator, Nephrology Unit, Centre Hospitalo-Universitaire de Limoges
5 Languedoc-Roussillon coordinator, Nephrology Unit, Clinique des Genêts, Narbonne
6 Auvergne coordinator, Nephrology Unit, Centre Hospitalier de Montluçon
7 Champagne-Ardenne coordinator, Nephrology Unit, Centre Hospitalo-Universitaire de Reims
8 Bretagne coordinator, Nephrology Unit, Centre Hospitalo-Universitaire
9 Lorraine coordinator, Nephrology Unit, Centre Hospitalo-Universitaire de Nancy, Vandoeuvre-lès Nancy
10 Rhône-Alpes coordinator, Centre Hospitalier Lyon-Sud, Nephrology Unit, Centre Hospitalier Lyon-Sud, Pierre-Benite
11 CIRE Ile de France, InVS, Paris, France

* To whom correspondence should be addressed.
Cécile Couchoud, E-mail: cecile.couchoud{at}biomedecine.fr



  Abstract

The French Renal Epidemiology and Information Network (REIN) registry began in 2002 to provide a tool for public health decision support, evaluation and research related to renal replacement therapies (RRT) for end-stage renal disease (ESRD). It relies on a network of nephrologists, epidemiologists, patients and public health representatives, coordinated regionally and nationally. Continuous registration covers all dialysis and transplanted patients. In 2003, 2070 patients started RRT, 7854 were on dialysis and 7294 lived with a functioning graft in seven regions (with a population of 16.5 million people). The overall crude annual incidence rate of RRT for ESRD was 123 per million population (p.m.p.) with significant differences in age-adjusted rates across regions, from 84 [95% confidence interval (CI): 74-94] to 155 [138-172] p.m.p. The principal causes of ESRD were hypertension (21%) and diabetic (20%) nephropathies. Initial treatment for ESRD was peritoneal dialysis for 15% of patients and a pre-emptive graft for 3%. The one-year survival rate was 81% [79-83] in the cohort of 2002-2003 incident patients. As of December 31, 2003, the overall crude prevalence was 898 [884-913] p.m.p, with 5% of patients receiving peritoneal dialysis, 47% on haemodialysis and 48% with a functioning graft. The experience in these seven regions over these two years clearly shows the feasibility of the REIN registry, which is progressively expanding to cover the entire country.

Keywords: end-stage renal disease registry; epidemiology; network; renal replacement therapy; public health decisional support systems; quality control.
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