Skip Navigation



NDT Advance Access published online on October 12, 2005
Nephrology Dialysis Transplantation, doi:10.1093/ndt/gfi196
This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
21/3/729    most recent
gfi196v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Covic, A.
Right arrow Articles by Goldsmith, D. J. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Covic, A.
Right arrow Articles by Goldsmith, D. J. A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author [2005]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Received July 1, 2005
Accepted September 9, 2005

Original Articles

Increased arterial stiffness in children on haemodialysis

Adrian Covic 1*, Nicoleta Mardare 1, Paul Gusbeth-Tatomir 1, Ovidiu Brumaru 2, Cristina Gavrilovici 2, Mihaela Munteanu 2, Octavian Prisada 1, and David J. A. Goldsmith 3

1 Dialysis and Transplantation Center, ‘C.I. Parhon’ University Hospital, Iasi, Romania
2 Nephrology and Dialysis Unit, ‘Sf. Maria’ Children Hospital, Iasi, Romania
3 Adult Renal Unit, Guy's Hospital, London, UK

* To whom correspondence should be addressed.
Adrian Covic, E-mail: acovic{at}xnet.ro



  Abstract

Background. Measures of aortic stiffness--aortic pulse wave velocity (PWV) and augmentation index (AIx)--have been shown to be powerful predictors of survival in adult haemodialysis (HD) patients. Very few data have been reported regarding arterial stiffness in paediatric renal populations.

Methods. PWV and aortic AIx were determined from contour analysis of arterial waveforms recorded by applanation tonometry using a SphygmoCor device in 14 children on HD (age = 14.1 years) and in 15 age, height matched children controls.

Results. Pre-HD AIx (29.7±15.4%) and PWV (6.6±1.0 m/s) were significantly higher compared with children controls (8.3±8.0% and 5.4±0.6 m/s, respectively, P<0.0001). The only significant difference between normal and HD children was BP level: 103/61 vs 114/72 mmHg, P<0.05. In children of HD patients, a multiple linear regression model including BP, age, height, weight, Ca and P levels as independent variables accounted for 57% of the variability in AIx. Dialysis had no impact on AIx (post-HD: 28.5±12.7%) or on PWV (post-HD: 6.7±0.8 m/s).

Conclusions. We show, in this first-ever report of increased arterial stiffness in children on dialysis, that end-stage renal disease is associated with abnormalities in arterial wall elastic properties, comparable with adult levels, even in childhood. Most importantly, the absence of a discernalble amelioration with dialysis implies that purely structural and not functional alterations lie behind the increased arterial stiffness.

Keywords: arterial stiffness; haemodialysis; haemodynamic; intimamedia thickness; paediatric patients.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Nephrol Dial TransplantHome page
M. S. Utescu, A. LeBoeuf, N. Chbinou, S. Desmeules, M. Lebel, and M. Agharazii
The impact of arteriovenous fistulas on aortic stiffness in patients with chronic kidney disease
Nephrol. Dial. Transplant., November 1, 2009; 24(11): 3441 - 3446.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
I. Dursun, H. M Poyrazoglu, Z. Gunduz, H. Ulger, A. Yykylmaz, R. Dusunsel, T. Patyroglu, and M. Gurgoze
The relationship between circulating endothelial microparticles and arterial stiffness and atherosclerosis in children with chronic kidney disease
Nephrol. Dial. Transplant., August 1, 2009; 24(8): 2511 - 2518.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
E. Davidovich, M. Davidovits, B. Peretz, J. Shapira, and D. J. Aframian
The correlation between dental calculus and disturbed mineral metabolism in paediatric patients with chronic kidney disease
Nephrol. Dial. Transplant., August 1, 2009; 24(8): 2439 - 2445.
[Abstract] [Full Text] [PDF]

Home page
 pdiHome page
R. Shroff
MONITORING CARDIOVASCULAR RISK FACTORS IN CHILDREN ON DIALYSIS
Perit. Dial. Int., February 1, 2009; 29(Supplement_2): S173 - S175.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
O. Cseprekal, E. Kis, P. Schaffer, T. E. H. Othmane, B. Cs. Fekete, A. Vannay, A. J. Szabo, A. Remport, A. Szabo, T. Tulassay, et al.
Pulse wave velocity in children following renal transplantation
Nephrol. Dial. Transplant., January 1, 2009; 24(1): 309 - 315.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
R. C. Shroff, R. McNair, N. Figg, J. N. Skepper, L. Schurgers, A. Gupta, M. Hiorns, A. E. Donald, J. Deanfield, L. Rees, et al.
Dialysis Accelerates Medial Vascular Calcification in Part by Triggering Smooth Muscle Cell Apoptosis
Circulation, October 21, 2008; 118(17): 1748 - 1757.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
Y. Aggoun, N. J. Farpour-Lambert, L. M. Marchand, E. Golay, A. B.R. Maggio, and M. Beghetti
Impaired endothelial and smooth muscle functions and arterial stiffness appear before puberty in obese children and are associated with elevated ambulatory blood pressure
Eur. Heart J., March 2, 2008; 29(6): 792 - 799.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
R. C. Shroff, A. E. Donald, M. P. Hiorns, A. Watson, S. Feather, D. Milford, E. A. Ellins, C. Storry, D. Ridout, J. Deanfield, et al.
Mineral Metabolism and Vascular Damage in Children on Dialysis
J. Am. Soc. Nephrol., November 1, 2007; 18(11): 2996 - 3003.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
R.-E. W. Kavey, V. Allada, S. R. Daniels, L. L. Hayman, B. W. McCrindle, J. W. Newburger, R. S. Parekh, and J. Steinberger
Cardiovascular Risk Reduction in High-Risk Pediatric Patients: A Scientific Statement From the American Heart Association Expert Panel on Population and Prevention Science; the Councils on Cardiovascular Disease in the Young, Epidemiology and Prevention, Nutrition, Physical Activity and Metabolism, High Blood Pressure Research, Cardiovascular Nursing, and the Kidney in Heart Disease; and the Interdisciplinary Working Group on Quality of Care and Outcomes Research: Endorsed by the American Academy of Pediatrics
Circulation, December 12, 2006; 114(24): 2710 - 2738.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.