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NDT Advance Access published online on October 4, 2005
Nephrology Dialysis Transplantation, doi:10.1093/ndt/gfi180
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© The Author [2005]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Received July 30, 2005
Accepted September 6, 2005

Case Report

Infliximab and nephrotic syndrome

George Chin 1*, Grant Luxton 1, and Jennet M. Harvey 2

1 Renal Unit, Sir Charles Gairdner Hospital, Nedlands
2 Department of Pathology, University of Western Australia and PathCentre, Western Australia, Australia

* To whom correspondence should be addressed.
George Chin, E-mail: george.chin{at}phnt.swest.nhs.uk



  Abstract

Infliximab is a chimeric tumor necrosis factor-alpha (TNF-{alpha}) monoclonal antibody, which has been used extensively in patients with rheumatoid arthritis and inflammatory bowel disease. It also appears to be effective in other conditions such as psoriasis and ankylosing spondylitis. The major side effect of infliximab is infection. Renal complications are uncommon and not well recognized. This report describes a probable case of infliximab-induced membranous nephropathy.

Keywords: drug-induced; infliximab; nephrotic syndrome.
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