Skip Navigation



NDT Advance Access published online on September 6, 2005
Nephrology Dialysis Transplantation, doi:10.1093/ndt/gfi103
This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
21/1/93    most recent
gfi103v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Yishak, A. A.
Right arrow Articles by Orchard, T. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Yishak, A. A.
Right arrow Articles by Orchard, T. J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author [2005]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Received December 2, 2004
Accepted August 4, 2005

Original Articles

Novel predictors of overt nephropathy in subjects with type 1 diabetes. A nested case control study from the Pittsburgh Epidemiology of Diabetes Complications cohort

Aklilu A. Yishak 1, Tina Costacou 2, Gabriel Virella 3, Janice Zgibor 2, Linda Fried 4, Michael Walsh 2, Rhobert W. Evans 2, Maria Lopes-Virella 5, Valerian E. Kagan 6, James Otvos 7, and Trevor J. Orchard 2*

1 Department of Medicine, Renal Electrolyte Division, University of Pittsburgh School of Medicine, PA, USA
2 Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA, USA
3 Department of Microbiology and Immunology, Medical University of South Carolina, USA
4 Department of Medicine, Renal Electrolyte Division, University of Pittsburgh School of Medicine, PA, USA; Veterans Pittsburgh Health Care System of Pittsburgh, PA, USA
5 Department of Medicine, Ralph H. Johnson Veterans Administration Medical Center, Charleston, SC, USA
6 Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, PA, USA
7 LipoScience, Inc., Raleigh, North Carolina, USA

* To whom correspondence should be addressed.
Trevor J. Orchard, E-mail: tjo{at}pitt.edu



  Abstract

Background. Predictors of diabetic nephropathy are only partly known and traditional risk factors do not adequately explain disease risk. We thus examined novel risk factors for overt nephropathy (ON) in type 1 diabetes.

Methods. The EDC is a prospective study of childhood-onset type 1 diabetes. When first seen (1986-1988), mean age was 28 and diabetes duration 19 years. In the subsequent 10 years, 56 of 485 subjects without ON in 1986-88 developed ON. An age, duration (±3 years), and sex-matched control was identified for 47 cases. Forty-two matched pairs had available stored plasma samples obtained prior to ON onset in cases, and complete standard risk factor data.

Results. Cases had a higher baseline albumin excretion rate (AER), HbA1, pulse rate, non-HDL cholesterol, fibrinogen, small LDL and lower eGDR and LDL particle size compared to controls (all P values <0.05). Multiple measures of immune complexes were increased in cases (P<0.05), whereas borderline elevations were seen for total antioxidant reserve (P = 0.06) and retinol (P = 0.08). Multivariably, other than AER, LDL particle size and IgG-IC were predictive beyond the standard predictors.

Conclusion. Besides AER, the immunecomplexes and lipoprotein subclasses may provide additional information in the assessment of ON risk in type 1 diabetes.

Keywords: adhesion molecules; antioxidants; diabetic nephropathy; immune complexes; lipids.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Clin. Endocrinol. Metab.Home page
M. C. Monti, J. T. Lonsdale, C. Montomoli, R. Montross, E. Schlag, and D. A. Greenberg
Familial Risk Factors for Microvascular Complications and Differential Male-Female Risk in a Large Cohort of American Families with Type 1 Diabetes
J. Clin. Endocrinol. Metab., December 1, 2007; 92(12): 4650 - 4655.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
A. D. Paterson, B. N. Rutledge, P. A. Cleary, J. M. Lachin, R. S. Crow, and for the Diabetes Control and Complications Trial/E
The Effect of Intensive Diabetes Treatment on Resting Heart Rate in Type 1 Diabetes: The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study
Diabetes Care, August 1, 2007; 30(8): 2107 - 2112.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
P. V. Rao, X. Lu, M. Standley, P. Pattee, G. Neelima, G. Girisesh, K.V. Dakshinamurthy, C. T. Roberts Jr., and S. R. Nagalla
Proteomic Identification of Urinary Biomarkers of Diabetic Nephropathy
Diabetes Care, March 1, 2007; 30(3): 629 - 637.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
A. F. Saad, G. Virella, C. Chassereau, R. J. Boackle, and M. F. Lopes-Virella
OxLDL immune complexes activate complement and induce cytokine production by MonoMac 6 cells and human macrophages
J. Lipid Res., September 1, 2006; 47(9): 1975 - 1983.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.