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NDT Advance Access published online on July 26, 2005
Nephrology Dialysis Transplantation, doi:10.1093/ndt/gfi011
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© The Author [2005]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org
Received August 16, 2004
Accepted May 11, 2005

Original Articles

The relationship of plasma ghrelin level to energy regulation, feeding and left ventricular function in non-diabetic haemodialysis patients

Chia-Chu Chang 1, Ching-Hui Hung 2, Chaun-Shu Yen 3, Kai-Lin Hwang 4, and Ching-Yuang Lin 5*

1 Division of Nephrology, Department of Internal Medicine, Children's Hospital, Changhua, Taiwan; Institute of Medical Research, Chang Jung Christian University, Taiwan
2 Division of Cardiology, Department of Internal Medicine, Children's Hospital, Changhua, Taiwan
3 Department of Medical Nutrition Therapy & Food Service, Changhua Christian Hospital, Changhua, Taiwan
4 Department of Public Health, Chung Shan Medical University, Taichung, Taiwan
5 Department of Pediatrics, Children's Hospital, Changhua, Taiwan; Institute of Medical Research, Chang Jung Christian University, Taiwan

* To whom correspondence should be addressed.
Ching-Yuang Lin, E-mail: 100966{at}cch.org.tw



  Abstract

Objective. Inadequate plasma ghrelin levels determine the suppression of appetite, nutritional state and morbidity. We investigated the correlation between plasma ghrelin levels and appetite, nutritional status and cardiovascular morbidity in maintenance haemodialysis (HD) patients.

Methods. We measured plasma ghrelin levels at 2 h intervals during a 24 h period in 22 non-diabetic HD patients, who were grouped into normal intake or disturbed intake according to subjective global assessments, and in six healthy controls.

Results. A significant positive correlation existed between the 24 h plasma ghrelin profile and most time-specific plasma ghrelin levels in non-diabetic HD patients. Ghrelin levels in the abnormal intake group were higher than those in the normal intake group. A significant positive correlation exsisted between ghrelin and left ventricle functions, including left ventricle mass index (r = 0.75, P = 0.008), left ventricle mass (r = 0.57, P = 0.03) and interventricular septum thickness (r = 0.70, P = 0.009). An inverse correlation existed between plasma ghrelin and right ventricular dimension (r = -0.45, P = 0.035). Body mass index (r = -0.64, P = 0.033) and body fat content (r = -0.619, P = 0.002) had significant negative correlations with plasma ghrelin.

Conclusions. Anorexia was found in patients with higher plasma ghrelin levels. Plasma ghrelin levels in non-diabetic HD patients showed a significant correlation with left ventricular function.

Keywords: appetite; end-stage renal disease; ghrelin; left ventricular function.
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