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NDT Advance Access published online on June 21, 2005
Nephrology Dialysis Transplantation, doi:10.1093/ndt/gfh928
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© The Author [2005]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org
Received February 23, 2005
Accepted April 30, 2005

Original Articles

Effects of oral vitamin C supplementation on oxidative stress and inflammation status in haemodialysis patients

Christine Fumeron 1, Thao Nguyen-Khoa 2, Claudine Saltiel 1, Messeret Kebede 3, Claude Buisson 1, Tilman B. Drüeke 4, Bernard Lacour 3, and Ziad A. Massy 5*

1 AURA Centre Henri Küntziger, Necker Hospital, Paris, France
2 Biochemistry A Laboratory, Necker Hospital, Paris, France; INSERM U507, Necker Hospital, Paris, France
3 Biochemistry A Laboratory, Necker Hospital, Paris, France
4 INSERM U507, Necker Hospital, Paris, France
5 Divisions of Clinical Pharmacology and Nephrology, INSERM ERI-12, Amiens University Hospital and University of Picardie, Amiens, France

* To whom correspondence should be addressed.
Ziad A. Massy, E-mail: massy{at}u-picardie.fr



  Abstract

Background. There is increasing evidence for the presence of oxidative stress and vitamin C deficiency in dialysis patients. Limited data, however, are available regarding the effects of vitamin C supplementation on oxidative stress and inflammation markers in such patients.

Methods. We ran a prospective, randomized, open-label trial to assess the effects of oral vitamin C supplementation (250 mg three times per week) for 2 months on well-defined oxidative and inflammatory markers in 33 chronic haemodialysis (HD) patients.

Results. Normalization of plasma total vitamin C and ascorbate levels by oral vitamin C supplementation did not modify plasma levels of carbonyls, C-reactive protein and albumin, or erythrocyte concentrations of reduced and oxidized glutathione.

Conclusion. Short-term oral vitamin C supplementation did not modify well-defined oxidative/antioxidative stress and inflammation markers in HD patients. Whether a higher oral dose or the intravenous route can modify these markers remains to be determined.

Keywords: dialysis; inflammation; oxidative stress; vitamin C.
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