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NDT Advance Access published online on May 26, 2005
Nephrology Dialysis Transplantation, doi:10.1093/ndt/gfh912
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© The Author [2005]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org
Received November 25, 2004
Accepted April 5, 2005

Original Articles

Effect of vitamin E-bonded dialyzer on eosinophilia in haemodialysis patients

Kenichiro Kojima 1*, Kuniyoshi Oda 1, Hitoshi Homma 1, Kazushi Takahashi 1, Yoshiko Kanda 1, Taketoshi Inokami 1, and Shunya Uchida 1

1 Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan

* To whom correspondence should be addressed.
Kenichiro Kojima, E-mail: kojima{at}med.teikyo-u.ac.jp



  Abstract

Background. Eosinophilia in haemodialysis patients probably results from allergy to haemodialysis-related materials, including dialyzer membranes. We examined the effects of vitamin E-bonded dialyzers on eosinophil counts in haemodialysis patients.

Methods. We enrolled seven patients who were on regular haemodialysis and had sustained eosinophilia. White blood cell, eosinophil, CD4- and CD8-positive lymphocyte counts, and serum interleukin-5 (IL-5) and IgE levels were determined before, 2 and 4 weeks after switching to vitamin E-bonded dialyzers.

Results. Eosinophil and CD4-positive lymphocyte counts and serum IL-5 were significantly (P = 0.003, 0.003 and 0.031, respectively) decreased after switching to vitamin E-bonded dialyzers. CD8-positive lymphocyte counts and serum IgE levels were unaltered. Crossover tests in two cases reproduced the higher eosinophilia within 4 weeks after returning to the original non-vitamin E-bonded dialyzer.

Conclusion: Vitamin E-bonded dialyzers may ameliorate eosinophilia through a mechanism mediated by a decrease in IL-5 secretion by CD4-positive lymphocytes.

Keywords: CD4-positive lymphocyte; eosinophilia; haemodialysis; IL-5; vitamin E-bonded dialyzer.
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