Skip Navigation



NDT Advance Access published online on May 3, 2005
Nephrology Dialysis Transplantation, doi:10.1093/ndt/gfh842
This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
20/8/1610    most recent
gfh842v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Chung, F.-M.
Right arrow Articles by Lee, Y.-J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Chung, F.-M.
Right arrow Articles by Lee, Y.-J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author [2005]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org
Received November 12, 2004
Accepted March 16, 2005

Original Articles

Effect of alcohol consumption on estimated glomerular filtration rate and creatinine clearance rate

Fu-Mei Chung 1, Yi-Hsin Yang 2, Tien-Yu Shieh 2, Shyi-Jang Shin 3, Jack C.-R. Tsai 4, and Yau-Jiunn Lee 4*

1 Department of Clinical Research, Pingtung Christian Hospital, Pingtung 900, Taiwan; Graduate Institute of Dental Sciences, Kaohsiung Medical University, Kaohsiung 807, Taiwan
2 Graduate Institute of Oral Health Sciences, Kaohsiung Medical University, Kaohsiung 807, Taiwan
3 Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
4 Department of Clinical Research, Pingtung Christian Hospital, Pingtung 900, Taiwan

* To whom correspondence should be addressed.
Yau-Jiunn Lee, E-mail: t3275{at}ms25.hinet.net



  Abstract

Background. Moderate alcohol consumption is widely recognized as beneficial in the prevention of cardiovascular disease, yet the renal effects of alcohol intake are still controversial. The present study is designed to investigate the influence of alcohol consumption on calculated creatinine clearance rate (CCr) and glomerular filtration rate (GFR) in a Southern Taiwan Pai-Wan aboriginal community with a high prevalence of alcohol consumption.

Methods. This is a cross-sectional community-based study. The 1466 aboriginal subjects, 40-95 years of age, are a stratified random subpopulation identified during an integrative health care programme. They were sampled for drinking patterns. The main outcome measurements were serum creatinine, estimated CCr and GFR.

Results. Subjects with alcohol consumption had significantly higher levels of serum triglycerides, high-density lipoprotein cholesterol, uric acid, estimated CCr and GFR values than non-drinkers. Their blood pressure was also significantly higher. They had lower total cholesterol and low-density lipoprotein cholesterol concentrations. Increasing alcohol consumption was independently and significantly associated with a higher level of estimated CCr and GFR when analysed as both a categorical and continuous variable.

Conclusions. The present study shows that chronic alcohol consumption has a negative effect on blood pressure and lipid profile and stimulates the estimated GFR.

Keywords: alcohol; blood pressure; creatinine clearance rate; glomerular filtration rate.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Nephrol Dial TransplantHome page
S. L. White, K. R. Polkinghorne, A. Cass, J. E. Shaw, R. C. Atkins, and S. J. Chadban
Alcohol consumption and 5-year onset of chronic kidney disease: the AusDiab study
Nephrol. Dial. Transplant., August 1, 2009; 24(8): 2464 - 2472.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
A. S. Gueye, M. Chelamcharla, B. C. Baird, C. Nguyen, H. Tang, A. L. Barenbaum, J. K. Koford, F. Shihab, and A. S. Goldfarb-Rumyantzev
The association between recipient alcohol dependency and long-term graft and recipient survival
Nephrol. Dial. Transplant., March 1, 2007; 22(3): 891 - 898.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
K. Lhotta
The role of gender in estimating glomerular filtration rate
Nephrol. Dial. Transplant., March 1, 2006; 21(3): 819 - 819.
[Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
Y.-J. Lee
Reply
Nephrol. Dial. Transplant., March 1, 2006; 21(3): 819 - 820.
[Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.