NDT Advance Access published online on April 12, 2005
Nephrology Dialysis Transplantation, doi:10.1093/ndt/gfh793
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Department of Nephrology, University Hospitals La Paz, Madrid, Spain
* To whom correspondence should be addressed. Background. Studies on the evolution of peritoneal transport during the first year of peritoneal dialysis (PD) are scarce and their results are contradictory. The aim of the present study was to analyse the evolution of peritoneal transport and residual renal function during the first year on PD, and to determine the factors that may influence them. Methods. We studied 249 patients on continuous ambulatory PD with glucose exchange solutions (117 men, 132 women, mean age 51.9±16 years) 59 of whom had diabetes (25 type I). At baseline and after 1 year, we determined the mass transfer coefficients of urea (U-MTAC) and creatinine (Cr-MTAC), net ultrafiltration and residual renal function. Results. Residual renal function decreased significantly during the first year (from 3.9±2.8 to 2.4±2.2 ml/min, P<0.001). Both U-MTAC and Cr-MTAC decreased after 1 year [U-MTAC from 22.7±7.8 to 20.7±6.6 ml/min (P<0.001), Cr-MTAC from 10.5±5.3 to 10.1±4.6 ml/min (NS)]. The ultrafiltration capacity increased significantly (from 923±359 to 987 U 341 ml/4 h, P<0.001). The evolution of MTAC values was independent of age, sex, diabetes and amount of hypertonic glucose used. When patients were grouped according to their initial Cr-MTAC, we observed a tendency toward normalization of the parameters of peritoneal function. Patients with peritonitis (n = 88) showed a first year increase in Cr-MTAC, which was significantly higher than in patients without peritonitis (11.1±5 vs 9.5±4.2, P<0.01). Ultrafiltration decreased in patients with more than four accumulated days of peritonitis (from 1062±447 to 1024±340 ml/4 h, NS); it increased in patients without peritonitis. Conclusions. The peritoneal transport parameters tended toward normalization during the first year on PD, mainly with a decrease of small solute transport and an increase of ultrafiltration capacity. This evolution is independent of age, gender, diabetes and higher exposure to glucose in PD solutions. Peritonitis was the only independent factor that affected peritoneal function during the first year on peritoneal dialysis.
Received June 8, 2004
Accepted January 12, 2005
Original Articles
Factors influencing peritoneal transport parameters during the first year on peritoneal dialysis: peritonitis is the main factor
2 General Hospital, Segovia, Spain
3 La Princesa, Madrid, Spain
Gloria del Peso, E-mail: gpeso.hulp{at}salud.madrid.org
Abstract 
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  P. Kalk, M. Ruckert, M. Godes, K. von Websky, K. Relle, H.-H. Neumayer, B. Hocher, and S. Morgera Does endothelin B receptor deficiency ameliorate the induction of peritoneal fibrosis in experimental peritoneal dialysis? Nephrol. Dial. Transplant., November 26, 2009; (2009) gfp652v1. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Miyamoto, M. Tamura, N. Kabashima, R. Serino, T. Shibata, Y. Furuno, M. Miyazaki, R. Baba, N. Sato, Y. Doi, et al. An integrin-activating peptide, PHSRN, ameliorates inhibitory effects of conventional peritoneal dialysis fluids on peritoneal wound healing Nephrol. Dial. Transplant., November 19, 2009; (2009) gfp601v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Nishimura, Y. Ito, M. Mizuno, A. Tanaka, Y. Morita, S. Maruyama, Y. Yuzawa, and S. Matsuo Mineralocorticoid receptor blockade ameliorates peritoneal fibrosis in new rat peritonitis model Am J Physiol Renal Physiol, May 1, 2008; 294(5): F1084 - F1093. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. K.-T. Li and K. M. Chow MAXIMIZING THE SUCCESS OF PERITONEAL DIALYSIS IN HIGH TRANSPORTERS Perit. Dial. Int., June 1, 2007; 27(Supplement_2): S148 - S152. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-J. F. Reyes, M.-A. Bajo, C. Hevia, G. del Peso, S. Ros, A. G. de Miguel, A. Cirugeda, M.-J. Castro, J. A. Sanchez-Tomero, and R. Selgas Inherent high peritoneal transport and ultrafiltration deficiency: their mid-term clinical relevance Nephrol. Dial. Transplant., January 1, 2007; 22(1): 218 - 223. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. S. Rodrigues, M. Almeida, I. Fonseca, M. Martins, M. J. Carvalho, F. Silva, C. Correia, M. J. Santos, and A. Cabrita Peritoneal fast transport in incident peritoneal dialysis patients is not consistently associated with systemic inflammation Nephrol. Dial. Transplant., March 1, 2006; 21(3): 763 - 769. [Abstract] [Full Text] [PDF]
|
|