NDT Advance Access published online on March 22, 2005
Nephrology Dialysis Transplantation, doi:10.1093/ndt/gfh775
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Department of Nephrology, University Hospital Maastricht, The Netherlands
* To whom correspondence should be addressed. Background. Accumulation of larger molecular weight uraemic toxins molecules may have a negative effect on the cardiovascular and nutritional state of dialysis patients and influence uraemic symptomatology. Their clearance can be enhanced by the use of haemofiltration (HF). Methods. The effects of low-flux haemodialysis (HD) (ultrapure dialysate; polyamide membranes) and pre-dilution on-line HF (1:1 blood/substitution ratio; target filtration volume: 1.2 times body weight) on cardiovascular and nutritional parameters, interdialytic levels of uraemic toxins and quality of life (QOL; Laupacis questionnaire) were assessed during 1 year follow-up. Forty patients were randomized. Results. After 1 year, 27 patients were eligible for analysis (HF: 13 patients; HD: 14 patients). Left ventricular mass index did not change in the HF patients (127±33 Conclusions. No changes in cardiovascular parameters were observed during pre-dilution on-line HF compared with low-flux HD. Treatment with on-line HF resulted in marked changes in the uraemic toxicity profile, an improvement in physical well-being and a small improvement in nutritional state.
Received November 5, 2004
Accepted February 11, 2005
Original Articles
Pre-dilution on-line haemofiltration vs low-flux haemodialysis: a randomized prospective study
2 Department of Internal Medicine, The Netherlands
3 Department of Clinical Chemistry, University Hospital Maastricht, The Netherlands
4 Department of Nutrition, University Hospital Maastricht, The Netherlands
5 Department of Nutrition, Vie Curi, Venlo, The Netherlands
6 Department of Cardiology, University Hospital Maastricht, The Netherlands
7 Department of Nephrology, University Hospital Gent, Belgium
Jeroen P. Kooman, E-mail: jkoo{at}sint.azm.nl
Abstract 
131±36 g/m2 after 12 months) or in the HD group (135±34 138±32 g/m2). Also, there were no changes in pulse wave velocity, and 48 h systolic and diastolic blood pressures. Lean body mass, assessed by dual-energy X-ray absorptiometry, increased in the HF group (44.8±8.9 46.2±9.6 kg; P<0.05), but not in the HD group (49.4±9.2 50.6±8.8 kg), although differences between groups were not significant. Insulin-like growth factor-1 levels remained stable in the HF patients, but decreased in the HD group (P<0.05 between groups). QOL for physical symptoms improved in the HF group (4.2±1.2 5.0±1.1; P<0.05 within the HF group and P = 0.06 between groups), but not in the HD group (4.0±1.0 4.4±1.4). 
2-microglobulin, complement factor D and homocysteine decreased significantly in the HF but not in the HD group, whereas L-ADMA, leptin and advanced glycation end-products-related fluorescence did not change.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  I. Ledebo and P. J. Blankestijn Haemodiafiltration--optimal efficiency and safety NDT Plus, November 5, 2009; (2009) sfp149v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. A. Pedrini, A. Feliciani, S. Zerbi, G. Cozzi, and P. Ruggiero Optimization of mid-dilution haemodiafiltration: technique and performance Nephrol. Dial. Transplant., September 1, 2009; 24(9): 2816 - 2824. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. C. van der Weerd, E. L. Penne, M. A. van den Dorpel, M. P.C. Grooteman, M. J. Nube, M. L. Bots, P. M. ter Wee, and P. J. Blankestijn Haemodiafiltration: promise for the future? Nephrol. Dial. Transplant., February 1, 2008; 23(2): 438 - 443. [Full Text] [PDF]
|
|
|
|
|
|
A. Feliciani, M. A. Riva, S. Zerbi, P. Ruggiero, A. R. Plati, G. Cozzi, and L. A. Pedrini New strategies in haemodiafiltration (HDF): prospective comparative analysis between on-line mixed HDF and mid-dilution HDF Nephrol. Dial. Transplant., June 1, 2007; 22(6): 1672 - 1679. [Abstract] [Full Text] [PDF]
|
|