NDT Advance Access published online on March 15, 2005
Nephrology Dialysis Transplantation, doi:10.1093/ndt/gfh729
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 University of Alabama at Birmingham, AL, USA
* To whom correspondence should be addressed. Background. Infection is a common cause of mortality and morbidity in haemodialysis patients. Few prospective studies have examined the clinical consequences of infection-related hospitalizations in haemodialysis patients or the risk factors predictive of clinical outcomes. Methods. The outcomes of all first infection-related hospitalizations of patients enrolled in the HEMO Study were categorized in terms of mortality, requirement for intensive care unit (ICU) stay and length of hospitalization. In addition, the association of hospitalization outcomes with clinical and laboratory parameters was evaluated. Results. Among the 783 first infection-related hospitalizations, 57.7% had a severe outcome (death, ICU stay or hospitalization Conclusion. In summary, infection-related hospitalizations are associated with substantial morbidity. Patient age, serum albumin and infectious disease category are independently correlated with the hospitalization outcome, and can be used to estimate the likelihood of serious outcomes at the time of hospital admission.
Received November 3, 2004
Accepted January 12, 2005
Original Articles
The spectrum of infection-related morbidity in hospitalized haemodialysis patients
2 Cleveland Clinic, Cleveland, OH, USA
3 Emory University, Atlanta, GA, USA
4 University of Utah, Salt Lake City, UT, USA
5 Duke University, Durham, NC, USA
6 Washington University, St Louis, MO, USA
7 University of California, Davis, CA, USA
8 Beth Israel Medical Center, New York, NY, USA
9 Vanderbilt University, Nashville, TN, USA
Michael Allon, E-mail: mdallon{at}uab.edu
Abstract 
7 days). The likelihood of a severe outcome increased with patient age (P<0.0001) and with decreased serum albumin (P<0.001). The frequency of a severe outcome varied greatly by infectious disease category (P<0.001), being highest for cardiac infections (95.6%) and infection of unknown source (68.4%), and lowest for urinary tract infections (35.5%) and access-related infections (43.8%). On multivariate analysis, hospitalization outcome was independently associated with patient age, serum albumin and disease category, but not with the randomized Kt/V or flux, gender, race or diabetic status.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  L. S. Dalrymple and A. S. Go Epidemiology of Acute Infections among Patients with Chronic Kidney Disease Clin. J. Am. Soc. Nephrol., September 1, 2008; 3(5): 1487 - 1493. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Onder, J. Chandar, N. Simon, R. Diaz, O. Nwobi, C. L. Abitbol, and G. Zilleruelo Comparison of tissue plasminogen activator-antibiotic locks with heparin-antibiotic locks in children with catheter-related bacteraemia Nephrol. Dial. Transplant., August 1, 2008; 23(8): 2604 - 2610. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Onder, J. Chandar, A. A. Billings, N. Simon, R. Diaz, D. Francoeur, C. Abitbol, and G. Zilleruelo Comparison of Early versus Late Use of Antibiotic Locks in the Treatment of Catheter-Related Bacteremia Clin. J. Am. Soc. Nephrol., July 1, 2008; 3(4): 1048 - 1056. [Abstract] [Full Text] [PDF]
|
|