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NDT Advance Access published online on February 8, 2005
Nephrology Dialysis Transplantation, doi:10.1093/ndt/gfh707
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© The Author [2005]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org
Received October 15, 2003
Accepted January 15, 2005

Original Articles

Assessment of renal function in recently admitted critically ill patients with normal serum creatinine

Eric A. J. Hoste 1*, Jorn Damen 1, Raymond C. Vanholder 2, Norbert H. Lameire 2, Joris R. Delanghe 3, Kristof Van den Hauwe 1, and Francis A. Colardyn 1

1 Intensive Care Unit, Ghent University Hospital, De Pintelaan 185, 9000 Gent, Belgium
2 Renal Division, Ghent University Hospital, De Pintelaan 185, 9000 Gent, Belgium
3 Department of Clinical Chemistry, Ghent University Hospital, De Pintelaan 185, 9000 Gent, Belgium

* To whom correspondence should be addressed.
Eric A. J. Hoste, E-mail: Erik.Hoste{at}UGent.be



  Abstract

Background. Detection of renal dysfunction is important in critically ill patients, and in daily practice, serum creatinine is used most often. Other tools allowing the evaluation of renal function are the Cockcroft-Gault and MDRD (Modification of Diet in Renal Disease) equations. These parameters may, however, not be optimal for critically ill patients. The present study evaluated the value of a single serum creatinine measurement, within normal limits, and three commonly used prediction equations for assessment of glomerular function (Cockcroft-Gault, MDRD and the simplified MDRD formula), compared with creatinine clearance (Ccr) measured on a 1 h urine collection in an intensive care unit (ICU) population.

Methods. This was a prospective observational study. A total of 28 adult patients with a serum creatinine <1.5 mg/dl, within the first week of ICU admission, were included in the study. Renal function was assessed with serum creatinine, timed 1 h urinary Ccr, and the Cockcroft-Gault, MDRD and simplified MDRD equations.

Results. Serum creatinine was in the normal range in all patients. Despite this, measured urinary Ccr was <80 ml/min/1.73 m2 in 13 patients (46.4%), and <60 ml/min/1.73 m2 in seven patients (25%). Urinary creatinine levels were low, especially in patients with low Ccr, suggesting a depressed production of creatinine caused by pronounced muscle loss. Regression analysis and Bland-Altman plots revealed that neither the Cockcroft-Gault formula nor the MDRD equations were specific enough for assessment of renal function.

Conclusions. In recently admitted critically ill patients with normal serum creatinine, serum creatinine had a low sensitivity for detection of renal dysfunction. Furthermore, the Cockcroft-Gault and MDRD equations were not adequate in assessing renal function.

Keywords: creatinine clearance; glomerular filtration rate; kidney failure, acute; kidney function; prediction equations; serum creatinine.
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