Skip Navigation



NDT Advance Access published online on February 8, 2005
Nephrology Dialysis Transplantation, doi:10.1093/ndt/gfh696
This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
20/4/783    most recent
gfh696v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Montgomery Øien, C.
Right arrow Articles by Os, I.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Montgomery Øien, C.
Right arrow Articles by Os, I.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author [2005]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org
Received June 28, 2004
Accepted December 22, 2004

Original Articles

Gender imbalance among donors in living kidney transplantation: the Norwegian experience

Cecilia Montgomery Øien 1*, Anna Varberg Reisæter 2, Torbjørn Leivestad 3, Per Pfeffer 4, Per Fauchald 2, and Ingrid Os 5

1 Department of Pharmacotherapeutics, University of Oslo, Oslo, Norway; Department of Medicine, Section of Nephrology, St Olavs Hospital, Trondheim, Norway
2 Department of Medicine, Section of Nephrology, Rikshospitalet University Hospital, Oslo, Norway
3 Institute of Immunology, Department of Surgery, Rikshospitalet University Hospital, Oslo, Norway
4 Transplant Unit, Department of Surgery, Rikshospitalet University Hospital, Oslo, Norway
5 Department of Pharmacotherapeutics, University of Oslo, Oslo, Norway

* To whom correspondence should be addressed.
Cecilia Montgomery Øien, E-mail: cecilia.oien{at}stolav.no



  Abstract

Background. In living donor (LD) kidney transplantation, a predominance of female-to-male donations has been observed. Gender demographics of living donors and outcomes of LD kidney transplantations in Norway were assessed, as this has not been explored previously.

Methods. Data from the Norwegian Renal Registry of first LD kidney transplantations (n = 1319) in the period 1985-2002 were used.

Results. The majority of all LD was female (57.8%; P<0.001), while 62.7% of the recipients were men (P<0.001). Females dominated as donors in the spousal group and the parental group (P<0.0001). However, no gender difference was observed in the parental group when the recipients were <30 years old (P = 0.65). In opposite-sex pairs, female-to-male donations were as expected based on the incidence of end-stage renal disease. Donor sex affected neither the incidence of acute rejections nor graft survival. Serum creatinine was higher in renal allografts from female donors to male recipients in the first 4 years after transplantation. Donor age also had significant impact on graft function measured as serum creatinine.

Conclusions. Gender disparities in LD transplantation result from a higher proportion of female-to-female and a lower proportion of male-to-male donations than expected. Both donor age and donor sex influence graft function during the first years. Graft survival and acute rejection episodes appear not to be affected by donor sex in LD kidney transplantation.

Keywords: gender; graft function; graft survival; kidney transplantation; living donor.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.