Skip Navigation



NDT Advance Access published online on December 23, 2004
Nephrology Dialysis Transplantation, doi:10.1093/ndt/gfh597
This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
20/2/404    most recent
gfh597v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Stompór, T.
Right arrow Articles by Janusz-Grzybowska, E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Stompór, T.
Right arrow Articles by Janusz-Grzybowska, E.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nephrol Dial Transplant © ERA-EDTA 2004; all rights reserved
Received February 9, 2004
Accepted September 9, 2004

Original Articles

Changes in common carotid artery intima-media thickness over 1 year in patients on peritoneal dialysis

Tomasz Stompór 1*, Andrzej Krasniak 1, Wladyslaw Sulowicz 1, Aldona Dembinska-Kiec 2, Katarzyna Janda 1, Katarzyna Wójcik 1, Barbara Tabor 1, Martyna E. Kowalczyk-Michalek 1, Anna Zdzienicka 2, and Eve Janusz-Grzybowska 1

1 Chair and Department of Nephrology, Jagiellonian University, 15c Kopernika Str., 31-501 Cracow, Poland
2 Department of Clinical Biochemistry, Jagiellonian University, 15c Kopernika Str., 31-501 Cracow, Poland

* To whom correspondence should be addressed.
Tomasz Stompór, E-mail: stompin{at}mp.pl



  Abstract

Background. Accelerated atherosclerosis and vascular calcifications increase cardiovascular morbidity and mortality in patients on dialysis. Common carotid artery (CCA) intima-media thickness (IMT) is considered useful for imaging atherosclerosis non-invasively. Since chronic inflammation may accelerate atherosclerosis in end-stage renal disease patients, the aim of this 1 year study was to assess changes in CCA-IMT in stable peritoneal dialysis (PD) patients, and to search for possible associations between these changes and selected cytokines, acute phase proteins and other risk factors of atherosclerosis.

Methods. Of the original cohort of 61 stable patients on PD--28 female, 33 male; mean age 50.4±13.6 years; dialyse for a median of 17.5 months at inclusion (range 1-96 months)--47 patients survived the 1 year period on PD. CCA-IMT was assessed at baseline and after 12 months. Pro-inflammatory cytokines (IL-6, TNF{alpha}), acute phase proteins (CRP, fibrinogen), calcium-phosphate balance and lipid profile were assessed at baseline and after 6 and 12 months. Anthropometric parameters (age, weight, BMI, waist-to-hip ratio) were measured at baseline.

Results. The mean CCA-IMT at baseline, 0.66± 0.19 mm, increased by a mean of 0.098±0.17 to 0.76±0.21 mm (P<0.001) in 1 year. In 14 patients (29.8%) at least one plaque was found in the CCAs examined. At the end of follow-up: 28 patients (59.6%) had increases in CCA-IMT (from 0.63±0.2 to 0.83± 0.21 mm; P = 0.03), and 19 (40.4%) remained stable or even showed slight, but non-significant, decreases of CCA-IMT (from 0.72±0.17 to 0.66±0.17 mm, P = NS). The ‘progressors’ had significantly higher initial BMI (P<0.05), and mean concentrations of calcium (P = 0.005), IL-6 (P = 0.05), TNF{alpha} (P = 0.05), CRP (P = 0.005) and lower HDL-cholesterol than ‘non-progressors’. In univariate analysis, {Delta}CCA-IMT correlated positively with age (R = 0.32, P = 0.03), BMI (R = 0.29, P = 0.05) and mean concentrations of CRP (R = 0.37, P = 0.01), TNF{alpha} (0.52, P = 0.0002), but inversely with HDL-cholesterol (R = -0.37, P = 0.01). In multiple regression analysis, however, only age appeared to be independently associated with increase in CCA-IMT ({beta} = 0.37, P<0.01; R2 for the model 0.14).

Conclusions. Our results suggest a possible role of non-specific inflammation in the progression of atherosclerosis in patients treated with PD, in addition to age.

Keywords: atherosclerosis; chronic inflammation; intima-media thickness; peritoneal dialysis.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 pdiHome page
A. Hubalewska-Dydejczyk, T. Stompor, M. Kalembkiewicz, M. Krzanowski, R. Mikolajczak, A. Sowa-Staszczak, B. Tabor-Ciepiela, U. Karczmarczyk, B. Kusnierz-Cabala, and W. Sulowicz
IDENTIFICATION OF INFLAMED ATHEROSCLEROTIC PLAQUE USING 123I-LABELED INTERLEUKIN-2 SCINTIGRAPHY IN HIGH-RISK PERITONEAL DIALYSIS PATIENTS: A PILOT STUDY
Perit. Dial. Int., September 1, 2009; 29(5): 568 - 574.
[Abstract] [Full Text] [PDF]

Home page
 pdiHome page
E. Garcia-Lopez, J. J. Carrero, M. E. Suliman, B. Lindholm, and P. Stenvinkel
RISK FACTORS FOR CARDIOVASCULAR DISEASE IN PATIENTS UNDERGOING PERITONEAL DIALYSIS
Perit. Dial. Int., June 1, 2007; 27(Supplement_2): S205 - S209.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
H. H. Jung, S.-W. Kim, and H. Han
Inflammation, mineral metabolism and progressive coronary artery calcification in patients on haemodialysis
Nephrol. Dial. Transplant., July 1, 2006; 21(7): 1915 - 1920.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.