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NDT Advance Access published online on July 27, 2004
Nephrology Dialysis Transplantation, doi:10.1093/ndt/gfh413
© 2004 by European Renal Association - European Dialysis and Transplant Association
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Received August 30, 2003
Accepted June 18, 2004

Original Article

Antidiuretic action of oxytocin is associated with increased urinary excretion of aquaporin-2

Kwon Wook Joo 1, Un Sil Jeon 2, Gheun-Ho Kim 3, Jungwhan Park 1, Yoon Kyu Oh 4, Yon Su Kim 1, Curie Ahn 1, Suhnggwon Kim 1, Seong Yeon Kim 1, Jung Sang Lee 1, Jin Suk Han 1*

1 Department of Internal Medicine, Seoul National University, Clinical Research Institute of Seoul National University Hospital, Seoul, Korea
2 Department of Internal Medicine, Korea Cancer Center Hospital, Seoul, Korea
3 Department of Internal Medicine, Hanyang University, Seoul, Korea
4 Department of Internal Medicine, Eulji Medical College, Seoul, Korea

* To whom correspondence should be addressed. E-mail: jshan{at}snu.ac.kr.



  Abstract

Background. The antidiuretic effect of oxytocin in humans is controversial. Urinary excretion of aquaporin-2 (AQP2) can be used as an index of the action of vasopressin on the kidney. We investigated whether exogenous oxytocin affects urinary concentration and urinary AQP2 excretion in human beings.

Methods. Oxytocin was administered intravenously at a rate of 20 mU/min in 10 healthy volunteers, seven patients with central diabetes insipidus (CDI) and three patients with nephrogenic diabetes insipidus (NDI). On the next day, 2 µg of 1-desamino-8-d-arginine vasopressin (dDAVP) was injected subcutaneously. Two-hour urine was collected before and after the administration of oxytocin and dDAVP, and urinary AQP2 was measured semi-quantitatively by western analysis.

Results. Urine volume and free water clearance were decreased, and urine osmolality was increased by the administration of oxytocin or dDAVP in the normal volunteers and CDI patients. Urinary AQP2 excretion was increased by oxytocin infusion in the normal volunteers (from 34±12 to 326±120 densitometry unit (DU)/2 h) and in the CDI group (from 8±2 to 227±92 DU/2 h) (P<0.05), but not in the NDI group. dDAVP also had a similar but more potent effect on the urinary excretion of AQP2 in the normal and CDI groups.

Conclusions. Oxytocin has an antidiuretic effect and increases the urinary excretion of AQP2 in humans whose urinary concentration mechanism is preserved. These results suggest that AQP2 might have a regulatory role in the antidiuretic action of oxytocin in humans.

Keywords: antidiuretic; human; oxytocin; urinary AQP2.
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