Skip Navigation



NDT Advance Access published online on May 5, 2004
Nephrology Dialysis Transplantation, doi:10.1093/ndt/gfh213
© 2004 by European Renal Association - European Dialysis and Transplant Association
This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
19/7/1767    most recent
gfh213v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Thirumurugan, A.
Right arrow Articles by Mark Taylor, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Thirumurugan, A.
Right arrow Articles by Mark Taylor, C.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Received September 5, 2003
Accepted February 13, 2004

Original Article

Urinary L-lactate excretion is increased in renal Fanconi syndrome

Arumugavelu Thirumurugan 1, Andrew Thewles 2, Rodney D. Gilbert 3, Sally-Anne Hulton 1, David V. Milford 1, Christopher J. Lote 2, C. Mark Taylor 1*

1 Department of Nephrology, Birmingham Children's Hospital, Birmingham, UK
2 Division of Medical Science, University of Birmingham, Birmingham, UK
3 Department of Paediatric Nephrology, Southampton General Hospital, Southampton, UK

* To whom correspondence should be addressed. E-mail: cm.taylor{at}bch.nhs.uk.



  Abstract

Background. Measurement of L-lactate in body fluids is an established clinical tool to identify disorders of cellular respiration. However, there is very little known about the clinical value of urinary lactate measurements. We investigated urinary lactate excretion in children with renal Fanconi syndrome.

Methods. Freshly voided urine samples were obtained from children with Fanconi syndrome and controls both with and without renal disease. Urine lactate was estimated by conversion to pyruvate in the presence of lactate dehydrogenase and NAD. The NADH produced was measured photometrically. Urine lactate was factored for urine creatinine.

Results. Children with Fanconi syndrome had a significantly higher urine lactate/creatinine ratio [mean: 84 x 10-2 mmol/mmol; 95% confidence interval (CI): 40.8-127.1 x 10-2 mmol/mmol] than healthy controls (mean: 1.3 x 10-2 mmol/mmol; CI: 1.1-1.5 x 10-2 mmol/ mmol) and those with a variety of renal diseases (mean: 3.1 x 10-2 mmol/mmol; CI: 1.8-4.5 x  10-2 mmol/mmol).

Conclusions. Urinary lactate is increased in Fanconi syndrome. The increase is likely to be due to reduced lactate co-transport in the proximal tubule. Urinary lactate/creatinine has clinical utility as a sensitive test of disordered proximal renal tubular function.

Keywords: Fanconi syndrome; lactate co-transport; proximal tubule disorders; urinary lactate cystinosis


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 QJMHome page
A.M. Hall, R.J. Unwin, M.G. Hanna, and M.R. Duchen
Renal function and mitochondrial cytopathy (MC): more questions than answers?
QJM, October 1, 2008; 101(10): 755 - 766.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. Plata, C. R. Sussman, A. Sindic, J. O. Liang, D. B. Mount, Z. M. Josephs, M.-H. Chang, and M. F. Romero
Zebrafish Slc5a12 Encodes an Electroneutral Sodium Monocarboxylate Transporter (SMCTn): A COMPARISON WITH THE ELECTROGENIC SMCT (SMCTe/Slc5a8)
J. Biol. Chem., April 20, 2007; 282(16): 11996 - 12009.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.