Skip Navigation



NDT Advance Access published online on March 5, 2004
Nephrology Dialysis Transplantation, doi:10.1093/ndt/gfh137
© 2004 by European Renal Association - European Dialysis and Transplant Association
This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
19/6/1441    most recent
gfh137v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Torpey, N.
Right arrow Articles by Ross, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Torpey, N.
Right arrow Articles by Ross, C.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Received July 31, 2003
Accepted January 7, 2004

Original Article

Drug-induced tubulo-interstitial nephritis secondary to proton pump inhibitors: experience from a single UK renal unit

Nicholas Torpey 1*, Tim Barker 2, Calum Ross 1

1 Renal Unit, Norfolk and Norwich University Hospital, Norwich, UK
2 Department of Pathology, Norfolk and Norwich University Hospital, Norwich, UK

* To whom correspondence should be addressed. E-mail: ntorpey{at}waitrose.com.



  Abstract

Background. Acute tubulo-interstitial nephritis (TIN) is an important cause of acute renal failure, and is often caused by hypersensitivity to drugs. The aim of this study was to determine the aetiology of interstitial nephritis among an unselected cohort of patients, and to identify those drugs commonly implicated.

Methods. A single-centre retrospective analysis was carried out of renal biopsy results from 296 consecutive patients between 1995 and 1999.

Results. Acute TIN was identified in 24 (8.1%) biopsies. Eight out of 14 cases with presumed drug-related TIN could be attributed to the proton pump inhibitors omeprazole and lansoprazole. The two cases of lansoprazole-associated TIN are the first to be reported with this drug. The presentation and favourable response to treatment of these patients are described.

Conclusion. Drugs are the most common cause of interstitial nephritis in the population studied. Those drugs most commonly associated with interstitial nephritis were the proton pump inhibitors omeprazole and lansoprazole.

Keywords: acute tubulo-interstitial nephritis, drugs, proton pump inhibitors


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 NEJMHome page
T. I. Steinman, A. E. Samir, and L. D. Cornell
Case 27-2008 -- A 64-Year-Old Man with Abdominal Pain, Nausea, and an Elevated Level of Serum Creatinine
N. Engl. J. Med., August 28, 2008; 359(9): 951 - 960.
[Full Text] [PDF]

Home page
 NDT PlusHome page
F. Jouret, S. Differding, R. Lhommel, M. Jadoul, and M. Lambert
A mysterious 'homesickness'
NDT Plus, June 25, 2008; (2008) sfn093v1.
[Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.