Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (40)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Veenstra, J.
Right arrow Articles by Arisz, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Veenstra, J.
Right arrow Articles by Arisz, L.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nephrol Dial Transplant (1994) 9: 637-641
© 1994 European Renal Association-European Dialysis and Transplant Association

research-article

Relationship between elevated creatine phosphokinase and the clinical spectrum of rhabdomyolysis

J. Veenstra, W. M. Smit, R. T. Krediet and L. Arisz

Renal Unit, Department of Internal Medicine, Academic Medical Center Amsterdam, The Netherlands

Correspondence and offprint requests to: Correspondence and offprint requests to: R. T. Krediet, Renal Unit, Department of Internal Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands

The incidence, causes and complications of severe rhabdomyolysis (creatine phosphokinase (CK) ≥5000 U/l) were studied during a 7-year study period in a large university hospital population. This condition was present in 0.074% of all admitted patients. The mortality in the study group (n=93) was 32% and the incidence of acute renal failure (ARF) 51%. Ischaemia was the most frequent cause, and drugs, alcohol and/or coma were the second most common cause of severe rhabdomyolysis. Patients with rhabdomyolysis due to ischaemia were older, had ARF more often, and also had the highest mortality. Hyperkalaemia (potassium ≥5.5 mmol/1) occurred in 13% of the patients, and all of them had or developed an impaired renal function. Hypocalcaemia (calcium ≤2.00 mmol/1) was found in 41%. The incidence of ARF and electrolyte disturbances was higher in patients with CK levels exceeding 15 000 U/l. Mortality was significantly higher in patients with ARF. Plasma concentrations of potassium and calcium correlated better with the severity of renal failure than with the maximal height of plasma CK.

Keywords: acute renal failure; creatine phosphokinase; hyperkalaemia; hypocalcaemia; rhabdomyolysis


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 NEJMHome page
X. Bosch, E. Poch, and J. M. Grau
Rhabdomyolysis and Acute Kidney Injury
N. Engl. J. Med., July 2, 2009; 361(1): 62 - 72.
[Full Text] [PDF]

Home page
 Hum Exp ToxicolHome page
H. Talaie, A. Pajouhmand, M. Abdollahi, R. Panahandeh, H. Emami, S. Hajinasrolah, and M. Tghaddosinezhad
Rhabdomyolysis among acute human poisoning cases
Human and Experimental Toxicology, July 1, 2007; 26(7): 557 - 561.
[Abstract] [PDF]

Home page
 CJASNHome page
J. A. Jaffe and P. L. Kimmel
Chronic Nephropathies of Cocaine and Heroin Abuse: A Critical Review
Clin. J. Am. Soc. Nephrol., July 1, 2006; 1(4): 655 - 667.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
D. S. Grover, M. G. Atta, J. A. Eustace, T. S. Kickler, and D. M. Fine
Lack of clinical utility of urine myoglobin detection by microconcentrator ultrafiltration in the diagnosis of rhabdomyolysis
Nephrol. Dial. Transplant., October 1, 2004; 19(10): 2634 - 2638.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
J. A. Henry
Metabolic consequences of drug misuse
Br. J. Anaesth., July 1, 2000; 85(1): 136 - 142.
[Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.