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NDT Advance Access originally published online on April 17, 2009
Nephrology Dialysis Transplantation 2009 24(9):2752-2754; doi:10.1093/ndt/gfp166
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© The Author [2009]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org


Varicella as a trigger of atypical haemolytic uraemic syndrome associated with complement dysfunction: two cases

Theresa Kwon1, Alexandre Belot2, Bruno Ranchin2, Véronique Baudouin1, Véronique Fremeaux-Bacchi3, Marie-Agnès Dragon-Durey3, Pierre Cochat2 and Chantal Loirat1

1 Pediatric Nephrology Department, Hôpital Robert Debré, Assistance Publique–Hôpitaux de Paris, Université Paris 7, Paris 2 Pediatric Nephrology Department, Hôpital Femme Mère Enfant, Hospices Civils de Lyon, Université de Lyon, Lyon 3 Biological Immunology Department, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris, Université Paris 5, Paris, France

Correspondence and offprint requests to: Theresa Kwon; E-mail: theresa.kwon{at}rdb.aphp.fr



  Abstract

We report two cases of children who presented with haemolytic uraemic syndrome following varicella infection. One of them had a membrane cofactor protein mutation, and the other had anti-factor H antibodies. These observations show that infectious agents such as varicella-zoster virus may be the trigger of haemolytic uraemic syndrome in patients with complement dysregulation.

Keywords: anti-factor H antibodies; haemolytic uraemic syndrome; MCP mutation; varicella

Received for publication: 20. 2.09
Accepted in revised form: 20. 3.09


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