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NDT Advance Access originally published online on February 11, 2009
Nephrology Dialysis Transplantation 2009 24(5):1695-1696; doi:10.1093/ndt/gfp032
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© The Author [2009]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org


Membranous glomerulonephritis—an under-reported histological finding in multiple myeloma

E-mail: a.abraham@aintree.nhs.uk

The first 10% of the full text of this article appears below.

Sir,

Plasma cell dyscrasias are characterized by clonal proliferation of plasma cells derived from B-lymphocytes. Renal involvement is well recognized in patients with all types of plasma cell dyscrasias including multiple myeloma. In patients with ‘myeloma kidney’, the commonest histological finding described is tubular light-chain deposition disease. Tubulo-interstitial nephritis, amyloid deposition and infarcts have also been demonstrated but the presentation with membranous glomerulonephritis has never been reported. Herein we describe two patients who had nephrotic syndrome associated with multiple myeloma and were found to have membranous glomerulonephritis.

An 80-year-old male . . . [Full Text of this Article]

Jecko Thachil1, Walid Sadik2, Howida Shawki3 and Kottarathil A. Abraham4

1 Department of Haematology, University of Liverpool 2 Department of Haematology, University Hospital Aintree 3 Department of Pathology, Royal Liverpool University Hospital, UK 4 Department of Nephrology, University Hospital Aintree


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