Skip Navigation


NDT Advance Access originally published online on June 25, 2009
Nephrology Dialysis Transplantation 2009 24(11):3540-3542; doi:10.1093/ndt/gfp314
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
24/11/3540    most recent
gfp314v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Jacquet, A.
Right arrow Articles by Durrbach, A.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jacquet, A.
Right arrow Articles by Durrbach, A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2009. Published by Oxford University Press [on behalf of ERA-EDTA]. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org


IgA nephropathy associated with ankylosing spondylitis is not controlled by infliximab therapy

Antoine Jacquet1, Helene Francois1, Carlos Frangie1, Yasmina Yahiaoui1, Sophie Ferlicot1, Corinne Micelli2, Xavier Mariette2 and Antoine Durrbach1

1 Department of Nephrology, Kremlin Bicêtre hospital 2 Department of Rheumatology, Kremlin Bicêtre hospital, 94275 Le Kremlin Bicetre, France

Correspondence and offprint requests to: antoine.jacquet{at}hotmail.fr



  Abstract

The association between seronegative spondyloarthro- pathies and IgA nephropathy is well documented, mainly in cases of ankylosing spondylitis (AS). However, although these diseases have been associated, the physiopathological links between each other appear unclear. Anti-TNF{alpha} agents have transformed the outcome of axial forms of AS resistant to conventional anti-inflammatory therapies. Infliximab, a monoclonal anti-TNF{alpha} antibody, has greatly improved the evolution of AS although several adverse events have been described. On the other hand, infliximab has been demonstrated to reduce renal symptoms associated with chronic inflammatory rheumatological diseases, such as amyloid A (AA) amyloidosis, but few data are available on its efficacy in controlling IgA nephropathy associated with AS [1,2]. We report here a case of IgA nephropathy associated with AS that became symptomatic, whereas infliximab therapy efficiently controlled the rheumatological disease. This suggests that even though infliximab therapy effectively controls rheumatological manifestations, it may not be able to prevent IgA nephropathy associated with AS. Thus, this case report illustrates the complexity of the physiopathology of both diseases.

Keywords: ankylosing spondylitis; IgA nephropathy; infliximab; TNFalpha

Received for publication: 6. 5.09
Accepted in revised form: 3. 6.09


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.