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NDT Advance Access originally published online on June 10, 2009
Nephrology Dialysis Transplantation 2009 24(10):3236-3239; doi:10.1093/ndt/gfp284
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© The Author [2009]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org


Remission of proteinuria with treatment of Actinomyces infection: eradicating a cause of secondary membranous glomerulopathy suppresses nephrotic syndrome

Soo Young Yoon1, Sang Choel Lee1, Young Jun Park2 and Seo-Hee Rha3

1 Departments of Nephrology 2 Gynecology, Kwandong University College of Medicine, Goyang 3 Department of Pathology, Dong-A University College of Medicine, Busan, Korea

Correspondence and offprint requests to: Soo Young Yoon; E-mail: diva502{at}kd.ac.kr



  Abstract

Eradication of a cause of secondary membranous glomerulopathy might suppress nephrotic syndrome. Here we report a patient with membranous nephropathy (MN), whose proteinuria entered complete remission after treating actinomycosis. A 45-year-old woman presented with nephrotic syndrome and was diagnosed as having MN. Her urine protein excretion was 5.3 g/day and the serum creatinine level was 70.7 µmol/L. When we searched for causes of secondary MN, pelvic actinomycosis was detected. After removing the pelvic abscess surgically, we administered amoxicillin for 6 months. Then, her proteinuria had decreased to <0.1 g/day, and since it entered remission, she has not relapsed.

Keywords: membranous nephropathy; nephrotic syndrome; pelvic actinomycosis; remission

Received for publication: 19.12.08
Accepted in revised form: 20. 5.09


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