Skip Navigation


NDT Advance Access originally published online on January 30, 2008
Nephrology Dialysis Transplantation 2008 23(7):2324-2328; doi:10.1093/ndt/gfm954
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
23/7/2324    most recent
gfm954v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Niizuma, S.
Right arrow Articles by Nakatani, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Niizuma, S.
Right arrow Articles by Nakatani, S.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author [2008]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved.For Permissions, please e-mail: journals.permissions@oxfordjournals.org


Decreased coronary flow reserve in haemodialysis patients

Shinnichiro Niizuma1, Shin Takiuchi1, Sadanori Okada2, Takeshi Horio1, Kei Kamide1, Hiroto Nakata1, Fumiki Yoshihara1, Satoko Nakamura1, Yuhei Kawano1, Hajime Nakahama1, Yoshitaka Iwanaga3 and Satoshi Nakatani3

1 Division of Hypertension and Nephrology 2 Division of Atherosclerosis and Diabetes 3 Division of Cardiology, National Cardiovascular Center, Fujishirodai 5-7-1, Suita 565-8565, Japan

Correspondence and offprint requests to: Hajime Nakahama, Division of Hypertension and Nephrology, National Cardiovascular Center, Fujishirodai 5-7-1, Suita 565-8565, Japan. E-mail: hnakaham{at}hsp.ncvc.go.jp



  Abstract

Background. Coronary flow reserve (CFR) reflects the functional capacity of microcirculation to adapt to blood demand during increased cardiac work.

Methods. Forty-one patients who had already undergone coronary angiography were studied. They consisted of 21 haemodialysis patients with no significant left anterior descending coronary artery (LAD) stenosis and 20 non-renal failure patients without LAD stenosis. We performed transthoracic Doppler recording of diastolic coronary flow velocity in the LAD at baseline and after maximal vasodilatation by adenosine triphosphate (ATP) infusion. CFR was defined as the ratio of hyperaemic to basal averaged peak flow velocity.

Results. Although the peak coronary velocities during hyperaemia were similar between the two groups, CFR was smaller in haemodialysis (HD) patients than in control subjects (1.96 ± 04 versus 2.3 ± 0.5, P = 0.001) due to the higher baseline peak coronary velocities in the former.

Conclusions. The elevated baseline peak coronary velocity may be caused by cardiac hypertrophy and anaemia in HD patients.

Keywords: anaemia; coronary flow reserve; echocardiography; haemodialysis; left ventricular

Received for publication: 3. 9.07
Accepted in revised form: 26.12.07


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Nephrol Dial TransplantHome page
B. Sobkowicz, A. Tomaszuk-Kazberuk, P. Kralisz, J. Malyszko, M. Kalinowski, T. Hryszko, R. Sawicki, S. Dobrzycki, and W. J. Musial
Coronary blood flow in patients with end-stage renal disease assessed by thrombolysis in myocardial infarction frame count method
Nephrol. Dial. Transplant., October 28, 2009; (2009) gfp533v1.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.