Skip Navigation


NDT Advance Access originally published online on March 1, 2008
Nephrology Dialysis Transplantation 2008 23(6):2084-2087; doi:10.1093/ndt/gfn092
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
23/6/2084    most recent
gfn092v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Andrassy, M.
Right arrow Articles by Schwenger, V.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Andrassy, M.
Right arrow Articles by Schwenger, V.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author [2008]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org


The patient with C-ANCA/PR3-ANCA-positive crescentic pauci-immune glomerulonephritis and recurrence of nephritic sediment

Martin Andrassy, Jeanne Sis, Rüdiger Waldherr, Martin Zeier and Vedat Schwenger

Department of Internal Medicine, University Hospital, Heidelberg, Germany

Correspondence and offprint requests to: Martin Andrassy, Medizinische Universitätsklinik Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany. E-mail: Martin_Andrassy@med.uni-heidelberg.de

Keywords: anti-glomerular basement membrane (GBM) antibodies; anti-neutrophil cytoplasmatic antibodies (ANCA); glomerulonephritis (GN); Goodpasture's disease

The first 150 words of the full text of this article appear below.



   Introduction
 
Recently it has been shown that in a significant number of patients with Goodpasture's disease and anti-GBM (glomerular basement membrane) antibodies, ANCA (anti-neutrophil cytoplasmatic antibodies) may coexist [1]. In this setting, ANCA is usually specific for P-ANCA and restricted to myeloperoxidase (MPO). In general both antibodies can be detected at the time of clinical presentation. C-ANCA/PR3-ANCA is rarely found in Goodpasture's disease [2]. Sequential development of anti-GBM nephritis and ANCA-associated disease has been described occasionally, again more with P-ANCA/MPO-ANCA rather than with C-ANCA/PR3-ANCA [3]. We report on a patient who first had C-ANCA/PR3-ANCA-positive renal vasculitis and then subsequently, after a long-term therapy-free interval, developed anti-GBM disease followed by repeated (renal) relapses of C-ANCA/PR3-ANCA-positive renal vasculitis despite continued immunosuppression.



   Case report
 
A 60-year-old white woman (85 kg, 1.63 cm) presented to our clinic in April 1990 with a 6-month history of recurrent arthritis of both upper ankle . . . [Full Text of this Article]



   Discussion
 

Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?